Division of Infectious Disease, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Infect Control Hosp Epidemiol. 2020 Dec;41(12):1375-1377. doi: 10.1017/ice.2020.331. Epub 2020 Jul 16.
Presently, evidence guiding clinicians on the optimal approach to safely screen patients for coronavirus disease 2019 (COVID-19) to a nonemergent hospital procedure is scarce. In this report, we describe our experience in screening for SARS-CoV-2 prior to semiurgent and urgent hospital procedures.
Retrospective case series.
A single tertiary-care medical center.
Our study cohort included patients ≥18 years of age who had semiurgent or urgent hospital procedures or surgeries.
Overall, 625 patients were screened for SARS-CoV-2 using a combination of phone questionnaire (7 days prior to the anticipated procedure), RT-PCR and chest computed tomography (CT) between March 1, 2020, and April 30, 2020.
Of the 625 patients, 520 scans (83.2%) were interpreted as normal; 1 (0.16%) had typical features of COVID-19; 18 scans (2.88%) had indeterminate features of COVID-19; and 86 (13.76%) had atypical features of COVID-19. In total, 640 RT-PCRs were performed, with 1 positive result (0.15%) in a patient with a CT scan that yielded an atypical finding. Of the 18 patients with chest CTs categorized as indeterminate, 5 underwent repeat negative RT-PCR nasopharyngeal swab 1 week after their initial swab. Also, 1 patient with a chest CT categorized as typical had a follow-up repeat negative RT-PCR, indicating that the chest CT was likely a false positive. After surgery, none of the patients developed signs or symptoms suspicious of COVID-19 that would indicate the need for a repeated RT-PCR or CT scan.
In our experience, chest CT scanning did not prove provide valuable information in detecting asymptomatic cases of SARS-CoV-2 (COVID-19) in our low-prevalence population.
目前,指导临床医生采用最佳方法对非紧急医院就诊的患者进行 2019 年冠状病毒病(COVID-19)筛查的证据很少。在本报告中,我们描述了在进行半紧急和紧急医院就诊之前对 SARS-CoV-2 进行筛查的经验。
回顾性病例系列。
一家单中心三级保健医疗中心。
我们的研究队列包括年龄≥18 岁的半紧急或紧急医院就诊或手术的患者。
2020 年 3 月 1 日至 4 月 30 日,共有 625 例患者使用电话问卷调查(预计就诊前 7 天)、实时逆转录聚合酶链反应(RT-PCR)和胸部计算机断层扫描(CT)相结合的方法筛查 SARS-CoV-2。
在 625 例患者中,520 例扫描(83.2%)结果正常;1 例(0.16%)具有 COVID-19 的典型特征;18 例(2.88%)CT 扫描结果不确定,具有 COVID-19 的不确定特征;86 例(13.76%)具有 COVID-19 的非典型特征。总共进行了 640 次 RT-PCR 检测,其中 1 例阳性(0.15%)患者的 CT 扫描结果为非典型。18 例 CT 扫描结果不确定的患者中,5 例在初始拭子后 1 周进行了重复阴性 RT-PCR 鼻咽拭子检测。另外,1 例 CT 扫描结果为典型的患者进行了重复阴性 RT-PCR,提示 CT 扫描可能为假阳性。手术后,没有患者出现疑似 COVID-19 的体征或症状,因此无需再次进行 RT-PCR 或 CT 扫描。
根据我们的经验,在低流行地区,胸部 CT 扫描在检测无症状 SARS-CoV-2(COVID-19)患者方面并未提供有价值的信息。