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在进行半紧急或紧急医院程序之前,对无症状患者进行胸部计算机断层扫描(CT)和 SARS-CoV-2 的 RT-PCR 筛查的效用。

The utility of chest computed tomography (CT) and RT-PCR screening of asymptomatic patients for SARS-CoV-2 prior to semiurgent or urgent hospital procedures.

机构信息

Division of Infectious Disease, Department of Medicine, Mayo Clinic, Rochester, Minnesota.

Department of Radiology, Mayo Clinic, Rochester, Minnesota.

出版信息

Infect Control Hosp Epidemiol. 2020 Dec;41(12):1375-1377. doi: 10.1017/ice.2020.331. Epub 2020 Jul 16.

DOI:10.1017/ice.2020.331
PMID:32669150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7417982/
Abstract

OBJECTIVE

Presently, evidence guiding clinicians on the optimal approach to safely screen patients for coronavirus disease 2019 (COVID-19) to a nonemergent hospital procedure is scarce. In this report, we describe our experience in screening for SARS-CoV-2 prior to semiurgent and urgent hospital procedures.

DESIGN

Retrospective case series.

SETTING

A single tertiary-care medical center.

PARTICIPANTS

Our study cohort included patients ≥18 years of age who had semiurgent or urgent hospital procedures or surgeries.

METHODS

Overall, 625 patients were screened for SARS-CoV-2 using a combination of phone questionnaire (7 days prior to the anticipated procedure), RT-PCR and chest computed tomography (CT) between March 1, 2020, and April 30, 2020.

RESULTS

Of the 625 patients, 520 scans (83.2%) were interpreted as normal; 1 (0.16%) had typical features of COVID-19; 18 scans (2.88%) had indeterminate features of COVID-19; and 86 (13.76%) had atypical features of COVID-19. In total, 640 RT-PCRs were performed, with 1 positive result (0.15%) in a patient with a CT scan that yielded an atypical finding. Of the 18 patients with chest CTs categorized as indeterminate, 5 underwent repeat negative RT-PCR nasopharyngeal swab 1 week after their initial swab. Also, 1 patient with a chest CT categorized as typical had a follow-up repeat negative RT-PCR, indicating that the chest CT was likely a false positive. After surgery, none of the patients developed signs or symptoms suspicious of COVID-19 that would indicate the need for a repeated RT-PCR or CT scan.

CONCLUSION

In our experience, chest CT scanning did not prove provide valuable information in detecting asymptomatic cases of SARS-CoV-2 (COVID-19) in our low-prevalence population.

摘要

目的

目前,指导临床医生采用最佳方法对非紧急医院就诊的患者进行 2019 年冠状病毒病(COVID-19)筛查的证据很少。在本报告中,我们描述了在进行半紧急和紧急医院就诊之前对 SARS-CoV-2 进行筛查的经验。

设计

回顾性病例系列。

设置

一家单中心三级保健医疗中心。

参与者

我们的研究队列包括年龄≥18 岁的半紧急或紧急医院就诊或手术的患者。

方法

2020 年 3 月 1 日至 4 月 30 日,共有 625 例患者使用电话问卷调查(预计就诊前 7 天)、实时逆转录聚合酶链反应(RT-PCR)和胸部计算机断层扫描(CT)相结合的方法筛查 SARS-CoV-2。

结果

在 625 例患者中,520 例扫描(83.2%)结果正常;1 例(0.16%)具有 COVID-19 的典型特征;18 例(2.88%)CT 扫描结果不确定,具有 COVID-19 的不确定特征;86 例(13.76%)具有 COVID-19 的非典型特征。总共进行了 640 次 RT-PCR 检测,其中 1 例阳性(0.15%)患者的 CT 扫描结果为非典型。18 例 CT 扫描结果不确定的患者中,5 例在初始拭子后 1 周进行了重复阴性 RT-PCR 鼻咽拭子检测。另外,1 例 CT 扫描结果为典型的患者进行了重复阴性 RT-PCR,提示 CT 扫描可能为假阳性。手术后,没有患者出现疑似 COVID-19 的体征或症状,因此无需再次进行 RT-PCR 或 CT 扫描。

结论

根据我们的经验,在低流行地区,胸部 CT 扫描在检测无症状 SARS-CoV-2(COVID-19)患者方面并未提供有价值的信息。

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