Mouse T-T hybridomas expressing receptors for syngeneic erythrocytes.

The report describes generation of mouse T-T hybridomas expressing receptors for murine erythrocytes. The obtained cell lines form 30-85% rosettes with mouse red cells without any preference for H-2 compatible erythrocytes. They do not bind xenogeneic erythrocytes. The role of Thy 1 antigen in constitution of receptors for erythrocytes was excluded since anti-Thy 1 monoclonal antibodies had no influence on rosetting activity. Rosette formation is inhibited by certain sugars showing the same pattern of inhibition as in the case of autologous rosette formation by CBA mouse thymocytes.