Shrihari T G
Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Bangalore, Karnataka, India.
Ann Ib Postgrad Med. 2019 Dec;17(2):111-114.
Endorphins are endogenous morphine, neuropeptides, produced in the pituitary gland in response to stress and pain. There are three types of endorphins beta-endorphins, enkephalins, and dynorphins binds to mu, kappa, and delta receptors situated on nervous system and immune cells. Cancer is a major threat to mankind killing millions of people around the world annually. There has been recent advancements in the field of surgery, chemotherapy, and radiotherapy, still the prognosis of cancer patients not improved much with increasing morbidity. We can't kill cancer cells without killing normal cells. Cancer cells and normal cells work alike. The aim of the review was to determine the anticancer activities of beta-endorphins.
Articles regarding endorphins and its therapeutic application in cancer were searched on PubMed and Google scholar. This review includes studies, reviews, clinical trials and key findings of my research were included in the manuscript.
Beta-endorphin is an abundant endorphin, potent than morphine, synthesized and secreted in the anterior pituitary gland, it is a precursor of POMC (proopiomelanocortin). It has got various mechanisms of action such as analgesic activity, anti-inflammatory activity, immune stimulatory activity, stress buster activity, and euphoric activity.
Beta endorphin is an abundant endogenous morphine used for natural holistic preventive, therapeutic, promotive, and palliative treatment of cancer without adverse effects and inexpensive.
内啡肽是内源性吗啡样神经肽，由垂体在应激和疼痛反应时产生。内啡肽有三种类型——β-内啡肽、脑啡肽和强啡肽，它们与位于神经系统和免疫细胞上的μ、κ和δ受体结合。癌症是对人类的重大威胁，每年在全球导致数百万人死亡。尽管近年来手术、化疗和放疗领域取得了进展，但癌症患者的预后并没有随着发病率的增加而有太大改善。我们无法在不杀死正常细胞的情况下杀死癌细胞。癌细胞和正常细胞的功能相似。本综述的目的是确定β-内啡肽的抗癌活性。
在PubMed和谷歌学术上搜索了关于内啡肽及其在癌症治疗应用方面的文章。本综述包括研究、综述、临床试验，我的研究的关键发现也纳入了本手稿。
β-内啡肽是一种丰富的内啡肽，比吗啡更有效，在前脑垂体中合成和分泌，它是阿片促黑激素皮质素原（POMC）的前体。它有多种作用机制，如镇痛活性、抗炎活性、免疫刺激活性、缓解压力活性和欣快活性。
β-内啡肽是一种丰富的内源性吗啡，可用于癌症的自然整体预防、治疗、促进和姑息治疗，无不良反应且成本低廉。
