饮用绿茶对血糖控制的影响：随机对照试验的系统评价和荟萃分析

Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials.

作者信息

Xu Renfan, Bai Yang, Yang Ke, Chen Guangzhi

机构信息

Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 P.R. China.

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 P.R. China.

出版信息

Nutr Metab (Lond). 2020 Jul 10;17:56. doi: 10.1186/s12986-020-00469-5. eCollection 2020.

BACKGROUND

The results of human clinical trials investigating the effects of green tea on glycemic control are inconsistent.

METHODS

We conducted a systematic review and meta-analysis of RCTs that examined the effects of green tea supplementation on glycemic control. A literature search in PubMed, Embase, and Cochrane Library databases for RCTs that investigated the effect of green tea consumption on glycemic control was performed up to February 2020. A random-effects model was used to estimate weighted mean difference (WMD) with 95% confidence intervals (CIs).

RESULTS

Twenty-seven trials involving 2194 subjects were included in the meta-analysis. The pooled results showed that green tea significantly lowered fasting blood glucose by - 1.44 mg/dL (95%CI:-2.26, - 0.62 mg/dL; < 0.001) with no obvious heterogeneity ( = 7.7%). However, green tea consumption did not significantly affect fasting insulin and HbA1c values. The mean differences were - 0.46μIU/mL (95% CI: - 1.10, 0.17IU/mL; = 0.21) for fasting insulin and - 0.06%; (95% CI: - 0.12, 0.01%; = 0.07) for HbA concentrations. Heterogeneity was significant in fasting insulin ( = 46.8%) and mild in HbA ( = 1.7%).

CONCLUSIONS

In short-term trials, green tea supplementation significantly reduced fasting glucose, but had no significant effect on fasting insulin and HbA. Long-term trials assessing the effects of green tea supplementation on glycemic control are needed.

背景

关于绿茶对血糖控制影响的人体临床试验结果并不一致。

方法

我们对研究补充绿茶对血糖控制影响的随机对照试验（RCT）进行了系统评价和荟萃分析。截至2020年2月，在PubMed、Embase和Cochrane图书馆数据库中检索了研究饮用绿茶对血糖控制影响的RCT。采用随机效应模型估计加权平均差（WMD）及其95%置信区间（CI）。

结果

荟萃分析纳入了27项试验，涉及2194名受试者。汇总结果显示，绿茶可使空腹血糖显著降低-1.44mg/dL（95%CI：-2.26，-0.62mg/dL；P<0.001），且无明显异质性（I²=7.7%）。然而，饮用绿茶对空腹胰岛素和糖化血红蛋白（HbA1c）值没有显著影响。空腹胰岛素的平均差值为-0.46μIU/mL（95%CI：-1.10，0.17IU/mL；P=0.21），HbA1c浓度的平均差值为-0.06%（95%CI：-0.12，0.01%；P=0.07）。空腹胰岛素的异质性显著（I²=46.8%），HbA1c的异质性较轻（I²=1.7%）。