Yu Jinyue, Song Peige, Perry Rachel, Penfold Chris, Cooper Ashley R
Division of Medicine, School of life and Medical Science, University College London, London, UK.
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
Diabetes Metab J. 2017 Aug;41(4):251-262. doi: 10.4093/dmj.2017.41.4.251.
Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM). Ovid MEDLINE, Embase, AMED, Web of Science, and the Cochrane Library were searched up to April 2017 for randomised controlled trials of participants with pre-diabetes or T2DM, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycemic control between GT/GTE and placebo groups. Six studies (n=382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for glycosylated hemoglobin (HbA1c: SMD, -0.32; 95% confidence interval [CI], -0.86 to 0.23), homeostatic model assessment for insulin resistance (HOMA-IR: SMD, 0.10; 95% CI, -0.17 to 0.38), fasting insulin (SMD, -0.25; 95% CI, -0.64 to 0.15), and fasting glucose (SMD, -0.10; 95% CI, -0.50 to 0.30). No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin, or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
绿茶或绿茶提取物（GT/GTE）已被证明可降低胰岛素抵抗并改善血糖控制。然而，这种有益健康作用的证据并不一致。本系统评价评估了GT/GTE对糖尿病前期/2型糖尿病（T2DM）患者胰岛素抵抗和血糖控制的影响。检索了截至2017年4月的Ovid MEDLINE、Embase、AMED、Web of Science和Cochrane图书馆，以查找糖尿病前期或T2DM参与者的随机对照试验，其中干预措施为GT/GTE。进行荟萃分析以评估GT/GTE组和安慰剂组之间胰岛素抵抗和血糖控制生物标志物的标准化平均差（SMD）。六项研究（n = 382）被纳入随机效应荟萃分析。总体而言，GT/GTE与安慰剂在糖化血红蛋白（HbA1c：SMD，-0.32；95%置信区间[CI]，-0.86至0.23）、胰岛素抵抗稳态模型评估（HOMA-IR：SMD，0.10；95%CI，-0.17至0.38）、空腹胰岛素（SMD，-0.25；95%CI，-0.64至0.15）和空腹血糖（SMD，-0.10；95%CI，-0.50至0.30）方面未发现差异。没有证据支持饮用GT/GTE可降低糖尿病前期/T2DM患者的HbA1c、HOMA-IR、空腹胰岛素或空腹血糖水平。然而，纳入的研究规模较小且质量参差不齐。
