用于神经损伤治疗的胶质细胞中的RNA干扰
RNA interference in glial cells for nerve injury treatment.
作者信息
Lin Junquan, Jo Seung Bin, Kim Tae-Hyun, Kim Hae-Won, Chew Sing Yian
机构信息
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of Korea.
出版信息
J Tissue Eng. 2020 Jul 6;11:2041731420939224. doi: 10.1177/2041731420939224. eCollection 2020 Jan-Dec.
Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.
RNA干扰驱动因子在操纵基因和蛋白质水平方面效力强大，能够恢复通常与损伤和疾病相关的失调mRNA表达。本综述总结了利用RNA干扰靶向神经胶质细胞治疗中枢神经系统神经损伤的潜力。此外，还将讨论递送这些RNA干扰效应物的各种方法。
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