Jiao Yang, Zhou Jialiang, Jin Yecheng, Yang Yingxin, Song Mingxu, Zhang Ling, Zhou Jiayan, Zhang Jiwei
College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
The Affiliated Hospital of Jiangnan University, Wuxi, China.
Front Oncol. 2020 May 15;10:639. doi: 10.3389/fonc.2020.00639. eCollection 2020.
Colorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in human cancer remain unclear. Here, we evaluated the expression of in CRC tissues and identified its potential targets. We found that is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. The high expression of can promote cancer cell proliferation substantially and invasion based on experiments. We also recognized that the targets the β-catenin in the signaling pathway to exert its carcinogenic activity. could serve as a promising prognostic predictor and a potential therapeutic target for further early diagnoses and treatments via a non-invasive method.
结直肠癌（CRC）是全球常见的癌症，5年生存率较低。最近，长链非编码RNA（lncRNAs）作为多种恶性肿瘤（包括CRC）中的癌基因或肿瘤抑制因子受到了充分研究。然而，它们在人类癌症中的生物学功能和潜在机制仍不清楚。在这里，我们评估了[具体lncRNA名称未给出]在CRC组织中的表达，并确定了其潜在靶点。我们发现，[具体lncRNA名称未给出]在大多数CRC患者中上调，这也与他们的恶性特征和不良预后显著相关。基于[具体实验未给出]实验，[具体lncRNA名称未给出]的高表达可显著促进癌细胞增殖和侵袭。我们还认识到，[具体lncRNA名称未给出]靶向Wnt信号通路中的β-连环蛋白以发挥其致癌活性。[具体lncRNA名称未给出]可作为一种有前景的预后预测指标，并通过非侵入性方法作为进一步早期诊断和治疗的潜在治疗靶点。
