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龋齿的遗传与易感性:一项基于社区的研究。

Inheritance and Susceptibility to Dental Caries: A Community-based Study.

作者信息

Khan Saima Y

机构信息

Department of Pediatric and Preventive Dentistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

出版信息

J Int Soc Prev Community Dent. 2020 Apr 2;10(2):148-155. doi: 10.4103/jispcd.JISPCD_384_19. eCollection 2020 Mar-Apr.

DOI:10.4103/jispcd.JISPCD_384_19
PMID:32670902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7339984/
Abstract

BACKGROUND

Effects of consanguineous marriage on human population are known. However, the inherited susceptibility to dental caries is unfortunately quite limited.

AIM

This study aimed to assess the dental caries status (DMFT/deft [decayed-missed-filling teeth/decayed-extracted-filled teeth] index) in children born out of consanguineous and non-consanguineous marriages.

DESIGN

Household survey using a cross-sectional study design was planned, with a sample size of 2000 comprising (1600 non-consanguineous and 400 consanguineous) children, aged 6-9 years. Household survey was also planned using a systematic random sampling. Researcher conducted the study by visiting every 10th household of every 10th ward of Aligarh city, Uttar Pradesh, India. Information of risk factors for dental caries (sociodemographic, birth order, oral hygiene, feeding practices) was recorded on a pretested questionnaire with clinical examination of DMFT/deft index.

ANALYSIS

Student test for equality of means and multivariate logistic regression were used.

RESULTS

By Student test for equality of means, D component ( = 0.003), d component ( < 0.001), and deft score ( < 0.001) were statistically significant in the consanguineous group. Multivariate logistic regression did not deduce any association of either of the study groups, but a significant association of risk factors with dental caries was observed.

CONCLUSION

Dental caries that has multifactorial etiology, both environment and genetic factors, had an influence on the causation of dental caries in this study.

摘要

背景

近亲结婚对人类群体的影响是已知的。然而,遗憾的是,关于龋齿的遗传易感性研究相当有限。

目的

本研究旨在评估近亲结婚和非近亲结婚所生孩子的龋齿状况(DMFT/乳牙龋失补牙指数[龋坏、缺失、已补牙数/龋坏、已拔牙、已补牙数])。

设计

计划采用横断面研究设计进行家庭调查,样本量为2000名6至9岁儿童(1600名非近亲结婚和400名近亲结婚的儿童)。还计划采用系统随机抽样进行家庭调查。研究人员通过走访印度北方邦阿里格尔市每10个街区中的第10个家庭来开展研究。通过预先测试的问卷记录龋齿危险因素(社会人口统计学、出生顺序、口腔卫生、喂养习惯)信息,并对DMFT/乳牙龋失补牙指数进行临床检查。

分析

采用学生t检验比较均值和多因素逻辑回归分析。

结果

通过学生t检验比较均值,近亲结婚组的D成分(P = 0.003)、d成分(P < 0.001)和乳牙龋失补牙得分(P < 0.001)具有统计学意义。多因素逻辑回归未推断出任何一个研究组之间存在关联,但观察到危险因素与龋齿之间存在显著关联。

结论

在本研究中,具有环境和遗传等多因素病因的龋齿对龋齿的发生有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d718/7339984/3c68d0bb0c3b/JISPCD-10-148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d718/7339984/3c68d0bb0c3b/JISPCD-10-148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d718/7339984/3c68d0bb0c3b/JISPCD-10-148-g001.jpg

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