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伤口愈合中的益生菌；一项研究。

Probiotic Bacteria in Wound Healing; An Study.

作者信息

Sinha Astha, Sagar Shakti, M Madhumathy, Jabez Osborne W

机构信息

Biomolecules Lab, School of Biosciences and Technology, Vellore Institute of Technology, Vellore - 632014, Tamil Nadu, India.

出版信息

Iran J Biotechnol. 2019 Dec 1;17(4):e2188. doi: 10.30498/IJB.2019.85188. eCollection 2019 Dec.

DOI:10.30498/IJB.2019.85188
PMID:32671124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7357700/
Abstract

BACKGROUND

Probiotics are food supplements that benefit the host by improving its intestinal microbial balance. Probiotics are used as diet supplements to prevent diarrhoea and improve lactose tolerance.

OBJECTIVES

The present study deals with the isolation of a potent probiotic strain capable of inducing healing properties in rat model.

MATERIALS AND METHODS

Probiotic VITSAMJ1 was isolated from goat milk using MRS media. The antimicrobial assay was carried out against S. aureus (MTCC 3160) and the wound healing properties were assessed on female Wistar rats. A 1.5 cm subcutaneous wound was induced in the rats, and a probiotic gel formulation was tropically applied onto the wounds. Tissue biopsy was carried out after days 1, 3, 5, 7, 9, and 11. Total leucocyte count and Histopathological analysis were performed after each interval.

RESULTS

VITSAMJ1 can be effectively used for wound healing.

CONCLUSION

VITSAMJ1 can be effectively used for wound healing.

摘要

背景

益生菌是通过改善宿主肠道微生物平衡而使其受益的食品补充剂。益生菌被用作饮食补充剂以预防腹泻并提高乳糖耐受性。

目的

本研究旨在分离出一种能够在大鼠模型中诱导愈合特性的强效益生菌菌株。

材料与方法

使用MRS培养基从山羊奶中分离出益生菌VITSAMJ1。对金黄色葡萄球菌（MTCC 3160）进行抗菌试验，并在雌性Wistar大鼠上评估伤口愈合特性。在大鼠身上造成1.5厘米的皮下伤口，并将益生菌凝胶制剂局部应用于伤口。在第1、3、5、7、9和11天后进行组织活检。在每个间隔期后进行白细胞总数和组织病理学分析。

结果

VITSAMJ1可有效用于伤口愈合。

结论

VITSAMJ1可有效用于伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/11afb605c68a/IJB-17-e2188-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/f115584cfb74/IJB-17-e2188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/570c6e056c4c/IJB-17-e2188-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/3ef1163fef86/IJB-17-e2188-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/ef9528d5ebd6/IJB-17-e2188-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/11afb605c68a/IJB-17-e2188-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/f115584cfb74/IJB-17-e2188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/570c6e056c4c/IJB-17-e2188-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/3ef1163fef86/IJB-17-e2188-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/ef9528d5ebd6/IJB-17-e2188-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8967/7357700/11afb605c68a/IJB-17-e2188-g005.jpg

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