Togo Camille, Zidorio Ana Paula, Gonçalves Vivian, Botelho Patrícia, de Carvalho Kenia, Dutra Eliane
Graduate Program in Human Nutrition, Faculty of Health Sciences, University of Brasilia, Campus Universitario Darcy Ribeiro, Brasilia 70910-900, Brazil.
Clinical Nutrition Unit, University Hospital of Brasilia, Brasilia 70840-901, Brazil.
Nutrients. 2021 Dec 27;14(1):111. doi: 10.3390/nu14010111.
The use of probiotics is one of the emerging lines of treatment for wound healing. This systematic review aimed to summarize currently available evidence on the effect of oral or enteral probiotic therapy on skin or oral mucosal wound healing in humans. To verify the developments in this field and the level of available scientific evidence, we applied a broad search strategy with no restrictions on wound type, target population, probiotic strain, or intervention protocol used. This review included seven studies involving 348 individuals. Four studies reported positive outcomes for healing improvement after probiotic therapy, and none of the studies reported adverse effects or a marked increase in wound healing time. The positive or neutral results observed do not generate strong evidence regarding the effectiveness of probiotics for wound healing. However, they suggest a promising field for future clinical research where the probiotic strains used, type of wounds, and target population are controlled for.
使用益生菌是伤口愈合治疗中新兴的治疗方法之一。本系统评价旨在总结目前关于口服或肠内益生菌疗法对人类皮肤或口腔黏膜伤口愈合影响的现有证据。为了验证该领域的进展情况以及现有科学证据的水平，我们采用了广泛的检索策略，对伤口类型、目标人群、益生菌菌株或所采用的干预方案均无限制。本评价纳入了7项研究，涉及348名个体。4项研究报告了益生菌治疗后愈合改善的阳性结果，且没有研究报告不良反应或伤口愈合时间显著延长。观察到的阳性或中性结果并未产生关于益生菌对伤口愈合有效性的有力证据。然而，它们提示了一个有前景的未来临床研究领域，在此领域中，所使用的益生菌菌株、伤口类型和目标人群均受到控制。
