Shanghai Institute of Immunology, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Adv Exp Med Biol. 2020;1207:405-408. doi: 10.1007/978-981-15-4272-5_28.
Alterations of autophagy contribute to the progression of various autoimmune diseases, including systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and systemic sclerosis (SSc). In patients with SLE, autophagy defects result in poor clearance of phagocytic fragments and excessive secretion of inflammatory factors. The disorder of autophagy in IBD patients is closely related to the regulation of inflammatory factors and the clearance of pathogenic pathogens of enteropathy. The increase of autophagy in synovioblasts of RA patients will promote RA-associated synovitis. The autophagy of fibroblasts in SSc patients is dysfunctional, leading to overactive wound healing. Understanding the role of autophagy in the pathogenesis may give us hints on the therapy of autoimmune diseases.
自噬的改变导致多种自身免疫性疾病的进展，包括系统性红斑狼疮 (SLE)、炎症性肠病 (IBD)、类风湿关节炎 (RA) 和系统性硬皮病 (SSc)。在 SLE 患者中，自噬缺陷导致吞噬碎片清除不良和炎症因子过度分泌。IBD 患者的自噬紊乱与炎症因子的调节和肠病病原体的清除密切相关。RA 患者的滑膜成纤维细胞自噬增加会促进 RA 相关滑膜炎。SSc 患者成纤维细胞的自噬功能失调，导致过度活跃的伤口愈合。了解自噬在发病机制中的作用可能为自身免疫性疾病的治疗提供线索。
