Ma Shangying, Wang Xueyi, Lai Feifan, Lou Chenghua
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Biomed Pharmacother. 2020 Oct;130:110421. doi: 10.1016/j.biopha.2020.110421. Epub 2020 Jul 13.
Picrorhiza kurroa, the dried rhizome of Picrorhiza kurroa Royle ex Benth, is a famous Chinese herb that has been traditionally used in China. Picroside II (PII), a glycoside derivative, is the main bioactive constituent of Picrorhiza kurroa. In the past several decades, bioactive components from Picrorhiza kurroa have attracted the attention of researchers due to their promising therapeutic effects. A large number of studies have demonstrated the therapeutic potential of PII for the prevention and treatment of some diseases, such as organic ischemia/reperfusion (I/R) injury, liver damage, inflammation, cancer metastasis and angiogenesis. In the present paper, we aimed to provide an overview of the pharmacology of PII, focusing on its anti-oxidant, anti-inflammatory and anti-apoptotic activities. Meanwhile, the plant tissue distribution and pharmacokinetic properties were also described. Due to its beneficial pharmacological effects in I/R injury, PII may serve as a promising therapeutic agent for organic I/R injury prevention.
胡黄连，即胡黄连（Picrorhiza kurroa Royle ex Benth）的干燥根茎，是一种在中国传统上使用的著名中药材。胡黄连苷II（PII），一种糖苷衍生物，是胡黄连的主要生物活性成分。在过去几十年中，胡黄连的生物活性成分因其有前景的治疗作用而吸引了研究人员的关注。大量研究已经证明了PII在预防和治疗某些疾病方面的治疗潜力，如器官缺血/再灌注（I/R）损伤、肝损伤、炎症、癌症转移和血管生成。在本文中，我们旨在概述PII的药理学，重点关注其抗氧化、抗炎和抗凋亡活性。同时，还描述了其在植物组织中的分布和药代动力学特性。由于其在I/R损伤中具有有益的药理作用，PII可能成为预防器官I/R损伤的一种有前景的治疗药物。
