• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MAGI2-AS3 通过靶向 miR-525-5p/MXD1 轴抑制 MYC 信号通路抑制卵巢癌细胞增殖和迁移。

MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis.

机构信息

Department of Gynecology, the First Hospital of China Medical University, Shenyang, P.R. China.

Department of Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China.

出版信息

Cancer Med. 2020 Sep;9(17):6377-6386. doi: 10.1002/cam4.3126. Epub 2020 Jul 18.

DOI:10.1002/cam4.3126
PMID:32681706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7476821/
Abstract

Ovarian cancer (OV) is one of the most lethal gynecological malignance in females, and usually diagnosed at advanced stages. Long noncoding RNAs (lncRNAs) exhibit their crucial functions in modulatory mechanisms of cancers. Substantive studies have proven the anti-tumor role of MAGI2-AS3 in multiple cancers, but the physiological functions of MAGI2-AS3 in OV need more detailed explanations. The current study corroborated that overexpression of MAGI2-AS3 executed inhibitory activity in OV via hindering cell proliferation, cell cycle, migration as well as invasion while promoted apoptosis. Moreover MAGI2-AS3 bound with miR-525-5p and negatively regulated the expression of miR-525-5p. Further studies testified that MXD1 was a downstream target of miR-525-5p and the competing relationship between MAGI2-AS3 and MXD1 were confirmed by RNA pull down. Based on the combination between MAX and MYC, we analyzed the effects of MAGI2-AS3 on MXD1 and MYC, unveiling the competing relationship between MXD1 and MYC for binding to MAX. Finally, we constructed rescue assays to certify that MAGI2-AS3 suppressed the course of OV via enhancing MXD1 expression. In summary, MAGI2-AS3 repressed the progression of OV by targeting miR-525-5p/MXD1 axis, offering a novel insight into understanding OV at the molecular level.

摘要

卵巢癌 (OV) 是女性最致命的妇科恶性肿瘤之一，通常在晚期诊断。长链非编码 RNA (lncRNA) 在癌症的调节机制中发挥着重要作用。大量研究已经证明 MAGI2-AS3 在多种癌症中具有抗肿瘤作用，但 MAGI2-AS3 在 OV 中的生理功能需要更详细的解释。本研究证实，通过抑制细胞增殖、细胞周期、迁移和侵袭，促进细胞凋亡，MAGI2-AS3 过表达在 OV 中发挥抑制作用。此外，MAGI2-AS3 与 miR-525-5p 结合并负调控 miR-525-5p 的表达。进一步的研究证明，MXD1 是 miR-525-5p 的下游靶基因，并且通过 RNA 下拉证实了 MAGI2-AS3 和 MXD1 之间的竞争关系。基于 MAX 和 MYC 的结合，我们分析了 MAGI2-AS3 对 MXD1 和 MYC 的影响，揭示了 MXD1 和 MYC 之间竞争结合 MAX 的关系。最后，我们构建了挽救实验来证明 MAGI2-AS3 通过增强 MXD1 表达来抑制 OV 的发生。总之，MAGI2-AS3 通过靶向 miR-525-5p/MXD1 轴抑制 OV 的进展，为在分子水平上理解 OV 提供了新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/2f4284025546/CAM4-9-6377-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/f1f11eeb69b2/CAM4-9-6377-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/aff1e1ab508e/CAM4-9-6377-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/aa66bd59e26b/CAM4-9-6377-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/ff651e6e5570/CAM4-9-6377-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/2f4284025546/CAM4-9-6377-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/f1f11eeb69b2/CAM4-9-6377-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/aff1e1ab508e/CAM4-9-6377-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/aa66bd59e26b/CAM4-9-6377-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/ff651e6e5570/CAM4-9-6377-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5a9/7476821/2f4284025546/CAM4-9-6377-g005.jpg

相似文献

1
MAGI2-AS3 suppresses MYC signaling to inhibit cell proliferation and migration in ovarian cancer through targeting miR-525-5p/MXD1 axis.MAGI2-AS3 通过靶向 miR-525-5p/MXD1 轴抑制 MYC 信号通路抑制卵巢癌细胞增殖和迁移。
Cancer Med. 2020 Sep;9(17):6377-6386. doi: 10.1002/cam4.3126. Epub 2020 Jul 18.
2
LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.长链非编码 RNA MAGI2-AS3 通过靶向 miR-31-5p/TNS1 轴抑制膀胱癌进展。
Aging (Albany NY). 2020 Nov 20;12(24):25547-25563. doi: 10.18632/aging.104162.
3
LncRNA MAGI2-AS3 inhibits hepatocellular carcinoma cell proliferation and migration by targeting the miR-374b-5p/SMG1 signaling pathway.长链非编码 RNA MAGI2-AS3 通过靶向 miR-374b-5p/SMG1 信号通路抑制肝癌细胞增殖和迁移。
J Cell Physiol. 2019 Aug;234(10):18825-18836. doi: 10.1002/jcp.28521. Epub 2019 Mar 28.
4
MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis: New Clinical Insights.MAGI2-AS3和miR-374b-5p通过调节PTEN/AKT/IRF-3/IFN-β轴作为多发性硬化症的潜在调节因子：新的临床见解
ACS Chem Neurosci. 2023 Mar 15;14(6):1107-1118. doi: 10.1021/acschemneuro.2c00653. Epub 2023 Mar 6.
5
Long noncoding RNA MAGI2-AS3/miR-218-5p/GDPD5/SEC61A1 axis drives cellular proliferation and migration and confers cisplatin resistance in nasopharyngeal carcinoma.长链非编码 RNA MAGI2-AS3/miR-218-5p/GDPD5/SEC61A1 轴驱动鼻咽癌细胞增殖和迁移，并赋予顺铂耐药性。
Int Forum Allergy Rhinol. 2020 Aug;10(8):1012-1023. doi: 10.1002/alr.22562. Epub 2020 May 25.
6
lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis.长链非编码 RNA MAGI2-AS3 通过 miR-106a-5p/RAB31 轴抑制去势抵抗性前列腺癌的增殖和迁移。
Genomics. 2023 Mar;115(2):110599. doi: 10.1016/j.ygeno.2023.110599. Epub 2023 Mar 6.
7
Long Noncoding RNA MAGI2-AS3 Represses Cell Progression in Clear Cell Renal Cell Carcinoma by Modulating the miR-629-5p/PRDM16 Axis.长链非编码 RNA MAGI2-AS3 通过调控 miR-629-5p/PRDM16 轴抑制肾透明细胞癌细胞的进展。
Crit Rev Eukaryot Gene Expr. 2023;33(7):43-56. doi: 10.1615/CritRevEukaryotGeneExpr.2023048338.
8
Long noncoding RNA MAGI2-AS3 regulates CCDC19 expression by sponging miR-15b-5p and suppresses bladder cancer progression.长链非编码 RNA MAGI2-AS3 通过海绵吸附 miR-15b-5p 调节 CCDC19 的表达，从而抑制膀胱癌的进展。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):231-235. doi: 10.1016/j.bbrc.2018.11.013. Epub 2018 Nov 12.
9
Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma.靶向 miR-21 的 NL101 阻断了 c-Myc/Mxd1 循环，抑制了 B 细胞淋巴瘤的生长。
Theranostics. 2021 Jan 19;11(7):3439-3451. doi: 10.7150/thno.53561. eCollection 2021.
10
Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis.MAGI2-AS3 在脂多糖诱导的核髓细胞损伤中的作用通过调控 miR-374b-5p/白细胞介素-10 轴。
Immun Inflamm Dis. 2023 Apr;11(4):e772. doi: 10.1002/iid3.772.

引用本文的文献

1
Deciphering the mysteries of MEG3 LncRNA and its implications in genitourinary cancers.解读MEG3长链非编码RNA的奥秘及其在泌尿生殖系统癌症中的意义。
Front Oncol. 2025 Apr 2;15:1519103. doi: 10.3389/fonc.2025.1519103. eCollection 2025.
2
Latest Update on lncRNA in Epithelial Ovarian Cancer-A Scoping Review.上皮性卵巢癌中长链非编码RNA的最新进展——一项综述。
Cells. 2025 Apr 7;14(7):555. doi: 10.3390/cells14070555.
3
Ovarian cancer and the heart: pathophysiology, chemotherapy-induced cardiotoxicity, and new therapeutic strategies.

本文引用的文献

1
Inhibition of Myc transcriptional activity by a mini-protein based upon Mxd1.基于 Mxd1 的小分子蛋白抑制 Myc 转录活性。
FEBS Lett. 2020 May;594(10):1467-1476. doi: 10.1002/1873-3468.13759. Epub 2020 Mar 11.
2
Dysregulation of pseudogene/lncRNA-hsa-miR-363-3p-SPOCK2 pathway fuels stage progression of ovarian cancer.假基因/长链非编码RNA-hsa-miR-363-3p-SPOCK2通路失调促进卵巢癌分期进展。
Aging (Albany NY). 2019 Dec 3;11(23):11416-11439. doi: 10.18632/aging.102538.
3
MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.
卵巢癌与心脏：病理生理学、化疗引起的心脏毒性及新的治疗策略。
J Ovarian Res. 2025 Apr 5;18(1):72. doi: 10.1186/s13048-025-01636-z.
4
MAGI2-AS3 hypermethylated in promoter region promotes migration and invasion of head and neck squamous cell carcinoma via miRNA-31-5p/AR axis.启动子区域高甲基化的MAGI2-AS3通过miRNA-31-5p/AR轴促进头颈部鳞状细胞癌的迁移和侵袭。
Transl Oncol. 2025 Feb;52:102223. doi: 10.1016/j.tranon.2024.102223. Epub 2024 Dec 7.
5
Ten Hypermethylated lncRNA Genes Are Specifically Involved in the Initiation, Progression, and Lymphatic and Peritoneal Metastasis of Epithelial Ovarian Cancer.十个高甲基化 lncRNA 基因特异性参与上皮性卵巢癌的起始、进展以及淋巴和腹膜转移。
Int J Mol Sci. 2024 Nov 4;25(21):11843. doi: 10.3390/ijms252111843.
6
The roles of long non-coding RNAs in Alzheimer's disease diagnosis, treatment, and their involvement in Alzheimer's disease immune responses.长链非编码RNA在阿尔茨海默病诊断、治疗中的作用及其在阿尔茨海默病免疫反应中的参与情况。
Noncoding RNA Res. 2024 Mar 16;9(3):659-666. doi: 10.1016/j.ncrna.2024.03.008. eCollection 2024 Sep.
7
Identification and Interaction Analysis of Molecular Markers in Pancreatic Ductal Adenocarcinoma by Bioinformatics and Next-Generation Sequencing Data Analysis.基于生物信息学和二代测序数据分析的胰腺导管腺癌分子标志物鉴定及相互作用分析
Bioinform Biol Insights. 2023 Jul 25;17:11779322231186719. doi: 10.1177/11779322231186719. eCollection 2023.
8
Fucoxanthin suppresses the malignant progression of ovarian cancer by inactivating STAT3/c-Myc signaling.岩藻黄质通过使信号转导和转录激活因子3/原癌基因c-Myc信号失活来抑制卵巢癌的恶性进展。
Am J Transl Res. 2023 Apr 15;15(4):2528-2540. eCollection 2023.
9
Role of lncRNA MAGI2-AS3 in lipopolysaccharide-induced nucleus pulposus cells injury by regulating miR-374b-5p/interleukin-10 axis.MAGI2-AS3 在脂多糖诱导的核髓细胞损伤中的作用通过调控 miR-374b-5p/白细胞介素-10 轴。
Immun Inflamm Dis. 2023 Apr;11(4):e772. doi: 10.1002/iid3.772.
10
Differential Regulation of Genes by the Glucogenic Hormone Asprosin in Ovarian Cancer.生糖激素阿朴脂蛋白在卵巢癌中对基因的差异调控
J Clin Med. 2022 Oct 8;11(19):5942. doi: 10.3390/jcm11195942.
miR-525-5p 通过阻断 UBE2C/ZEB1/2 信号轴抑制宫颈癌转移和抗失巢凋亡。
Dig Dis Sci. 2020 Aug;65(8):2442-2451. doi: 10.1007/s10620-019-05916-9. Epub 2019 Nov 2.
4
The MicroRNA-382-5p/MXD1 Axis Relates to Breast Cancer Progression and Promotes Cell Malignant Phenotypes.miR-382-5p/MXD1 轴与乳腺癌的进展有关，并促进细胞恶性表型。
J Surg Res. 2020 Feb;246:442-449. doi: 10.1016/j.jss.2019.09.018. Epub 2019 Oct 18.
5
LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer.长链非编码 RNA FLVCR1-AS1 通过调节 miR-513/YAP1 信号通路促进卵巢癌细胞的进展、迁移、侵袭和 EMT 过程。
J Exp Clin Cancer Res. 2019 Aug 14;38(1):356. doi: 10.1186/s13046-019-1356-z.
6
Expression of long non-coding RNA MAGI2‑AS3 in human gliomas and its prognostic significance.长链非编码 RNA MAGI2-AS3 在人脑胶质瘤中的表达及其预后意义。
Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3455-3460. doi: 10.26355/eurrev_201904_17710.
7
Long non-coding RNA MAGI2-AS3 inhibits breast cancer cell migration and invasion via sponging microRNA-374a.长链非编码 RNA MAGI2-AS3 通过海绵吸附 microRNA-374a 抑制乳腺癌细胞迁移和侵袭。
Cancer Biomark. 2019;24(3):269-277. doi: 10.3233/CBM-182216.
8
LncRNA LINC00319 accelerates ovarian cancer progression through miR-423-5p/NACC1 pathway.长链非编码 RNA LINC00319 通过 miR-423-5p/NACC1 通路促进卵巢癌细胞的进展。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):198-202. doi: 10.1016/j.bbrc.2018.11.006. Epub 2018 Nov 12.
9
Long noncoding RNA MAGI2-AS3 regulates CCDC19 expression by sponging miR-15b-5p and suppresses bladder cancer progression.长链非编码 RNA MAGI2-AS3 通过海绵吸附 miR-15b-5p 调节 CCDC19 的表达，从而抑制膀胱癌的进展。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):231-235. doi: 10.1016/j.bbrc.2018.11.013. Epub 2018 Nov 12.
10
SLC27A2 regulates miR-411 to affect chemo-resistance in ovarian cancer.SLC27A2 通过调节 miR-411 影响卵巢癌的化疗耐药性。
Neoplasma. 2018 Nov 15;65(6):915-924. doi: 10.4149/neo_2018_180122N48. Epub 2018 Sep 4.