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扁平苔藓的免疫组织化学研究

Immunohistochemical study of lichen planus.

作者信息

Shousha S, Svirbely J

出版信息

J Clin Pathol. 1977 Jun;30(6):569-74. doi: 10.1136/jcp.30.6.569.

DOI:10.1136/jcp.30.6.569
PMID:326819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476470/
Abstract

The distribution of IgM and IgG in 20 cases of lichen planus and five cases of non-specific inflammation were studied by the unlabelled antibody-enzyme (PAP) technique. Routine paraffin sections were used. In lichen planus deposits of immunoglobulins were seen in and around epithelial cells, in colloid bodies, at epidermo-dermal junctions, and in some inflammatory cells. All cases examined for IgM and eight out of 13 cases examined for IgG were positive. The peripheral migrating epidermal cells were mostly negative. The application of the PAP technique to skin biopsy and the significance of the findings in lichen planus are discussed.

摘要

采用非标记抗体酶（PAP）技术研究了20例扁平苔藓和5例非特异性炎症患者体内IgM和IgG的分布情况。使用常规石蜡切片。在扁平苔藓中，上皮细胞内外、胶样小体、表皮-真皮交界处及部分炎症细胞内可见免疫球蛋白沉积。检测的所有20例IgM病例及13例IgG病例中的8例呈阳性。外周游走的表皮细胞大多为阴性。文中讨论了PAP技术在皮肤活检中的应用及扁平苔藓中这些发现的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/00c5cda1f7fe/jclinpath00164-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/73acf56a2619/jclinpath00164-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/4e8df00a1d20/jclinpath00164-0077-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/8f9625111fe2/jclinpath00164-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/00c5cda1f7fe/jclinpath00164-0078-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/73acf56a2619/jclinpath00164-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/4e8df00a1d20/jclinpath00164-0077-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/8f9625111fe2/jclinpath00164-0078-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f32b/476470/00c5cda1f7fe/jclinpath00164-0078-b.jpg

相似文献

1
Immunohistochemical study of lichen planus.扁平苔藓的免疫组织化学研究
J Clin Pathol. 1977 Jun;30(6):569-74. doi: 10.1136/jcp.30.6.569.
2
Immunohistochemistry in lichen planus.
Dermatologica. 1979;159(2):137-44. doi: 10.1159/000250575.
3
[Coexistence of lichen planus and bullous pemphigoid (an immunofluorescence study of a "lichen pemphigoides") (author's transl)].扁平苔藓与大疱性类天疱疮的共存（“类天疱疮样扁平苔藓”的免疫荧光研究）（作者译）
Ann Dermatol Venereol. 1977 May;104(5):368-74.
4
Direct immunofluorescence in oral lichen planus.口腔扁平苔藓中的直接免疫荧光
Oral Surg Oral Med Oral Pathol. 1982 May;53(5):483-7. doi: 10.1016/0030-4220(82)90461-3.
5
Lichen planus dermopathy: demonstration of a lichen planus specific epidermal antigen in affected patients.扁平苔藓皮肤病：在患病患者中证实存在扁平苔藓特异性表皮抗原。
J Clin Lab Immunol. 1983 Feb;10(2):103-6.
6
Indirect immunofluorescence of oral lichen planus.
J Oral Pathol. 1986 Apr;15(4):218-20. doi: 10.1111/j.1600-0714.1986.tb00611.x.
7
Globular deposits of immunoglobulins and complement in the papillary dermis. Clinical significance.
Am J Clin Pathol. 1980 Apr;73(4):512-7. doi: 10.1093/ajcp/73.4.512.
8
[Lichen planus with linear IgG and C3 deposits at the dermal-epidermal junction (author's transl)].伴有真皮-表皮交界处线性IgG和C3沉积的扁平苔藓（作者译）
Dermatologica. 1981;163(1):117-24.
9
The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus.免疫球蛋白和纤维蛋白沉积在扁平苔藓中的诊断意义。
Br J Dermatol. 1975 Jul;93(1):17-24. doi: 10.1111/j.1365-2133.1975.tb06470.x.
10
[Serum immunoglobulins in patients with lichen ruber planus of the oral mucosa].[口腔黏膜扁平苔藓患者的血清免疫球蛋白]
Dtsch Zahnarztl Z. 1981 Mar;36(3):136-8.

引用本文的文献

1
Comparative study of number and distribution of IgG cells in oral lichen planus and oral lichenoid lesions.口腔扁平苔藓与口腔苔藓样病变中IgG细胞数量及分布的比较研究
Dent Res J (Isfahan). 2009 Spring;6(1):1-5.

本文引用的文献

1
Ultrastructural and light microscopic changes of the epidermo-dermal junction.
Trans St Johns Hosp Dermatol Soc. 1971;57(1):139-42.
2
Epidermal cell kinetics in lichen planus.扁平苔藓中的表皮细胞动力学
Br J Dermatol. 1973 Jan;88(1):37-45. doi: 10.1111/j.1365-2133.1973.tb06669.x.
3
An immunofluorescence study of lichen planus.
Br J Dermatol. 1974 Apr;90(4):365-71. doi: 10.1111/j.1365-2133.1974.tb06420.x.
4
The pathogenesis of lichen planus.
扁平苔藓的发病机制。
Br J Dermatol. 1972 Mar;86(3):302-5. doi: 10.1111/j.1365-2133.1972.tb02233.x.
5
The role of the epidermis in the histopathogenesis of lichen planus. Histochemical correlations.表皮在扁平苔藓组织病理学发病机制中的作用。组织化学相关性。
Arch Dermatol. 1972 Jan;105(1):81-6.
6
Hyaline bodies in subepidermal papillae. Immunohistochemical studies in several dermatoses.表皮下乳头体中的透明小体。几种皮肤病的免疫组织化学研究。
Arch Dermatol. 1969 Nov;100(5):610-7.
7
The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus.免疫球蛋白和纤维蛋白沉积在扁平苔藓中的诊断意义。
Br J Dermatol. 1975 Jul;93(1):17-24. doi: 10.1111/j.1365-2133.1975.tb06470.x.
8
Epidermal antigens in lichen planus.
Br J Dermatol. 1975 Jun;92(6):631-6. doi: 10.1111/j.1365-2133.1975.tb03142.x.
9
Identification of subpopulations of lymphocytes and macrophages in the infiltrate of lichen planus lesions of skin and oral mucosa.皮肤和口腔黏膜扁平苔藓病变浸润中淋巴细胞和巨噬细胞亚群的鉴定。
Br J Dermatol. 1976 May;94(5):529-34. doi: 10.1111/j.1365-2133.1976.tb05141.x.
10
Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material.未标记抗体-酶（PAP）法的背景染色及敏感性。与使用福尔马林固定石蜡包埋材料的过氧化物酶标记抗体夹心法的比较。
Histochemistry. 1975 Jun 5;43(3):291-4. doi: 10.1007/BF00499711.