School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
J Pharm Biomed Anal. 2020 Sep 5;188:113465. doi: 10.1016/j.jpba.2020.113465. Epub 2020 Jul 9.
Turmeric (Curcuma longa L.) is a popular herbal medicine worldwide. Curcuminoids and volatile constituents are its major bioactive components. To improve the quality control of turmeric, we determined the contents of three main curcuminoids in 160 batches of turmeric samples collected from five major production areas of China by HPLC, and analyzed the volatile components by GC/MS. The results indicated that samples with red cross sections (2.75 ± 0.82 mg/g) contained significantly higher amounts of curcuminoids than samples with yellow sections (1.23 ± 0.60 mg/g) (p < 0.001). This result was consistent with empirical standard of TCM pharmacists. The contents of curcuminoids in samples from Hainan (4.51±0.25%), Guizhou (3.17±0.41%), and Sichuan (2.25±0.54%) were relatively high and consistent. Moreover, the GC/MS profiles of turmeric may be affected by storage and processing. This study sets a good example for comprehensive quality control of herbal medicines.
姜黄（Curcuma longa L.）是一种在全球范围内广受欢迎的草药。姜黄素和挥发性成分是其主要的生物活性成分。为了提高姜黄的质量控制水平，我们采用高效液相色谱法（HPLC）测定了来自中国五个主要产区的 160 批姜黄样品中三种主要姜黄素的含量，并采用气相色谱/质谱法（GC/MS）对挥发性成分进行了分析。结果表明，横切面上呈红色的样品（2.75±0.82mg/g）中姜黄素类化合物的含量明显高于横切面上呈黄色的样品（1.23±0.60mg/g）（p<0.001）。这一结果与中药师的经验标准一致。来自海南（4.51±0.25%）、贵州（3.17±0.41%）和四川（2.25±0.54%）的样品中姜黄素类化合物的含量相对较高且一致。此外，姜黄的 GC/MS 图谱可能会受到储存和加工的影响。本研究为草药的全面质量控制树立了良好的范例。
