Departamento de Psicología Evolutiva y Didáctica, Universidad de Alicante, Alicante, España.
Departamento de Química Agrícola, Facultad de Química, Universidad de Murcia, Campus de Espinardo, Murcia, España; Departamento de Ingeniería Química, Facultad de Química, Universidad de Murcia, Campus de Espinardo, Murcia, España.
Rev Psiquiatr Salud Ment (Engl Ed). 2020 Jul-Sep;13(3):150-164. doi: 10.1016/j.rpsm.2020.06.002. Epub 2020 Jul 16.
In recent years, there has been an increase in studies of the implications of the gut microbiota (GM) in children with autism spectrum disorder (ASD). There is a hypothesis which propose a relationship between the emotional state and the abundance of intestinal microbes through the so-called microbiota-intestine-brain axis. In this sense, dysbiotic GM could be a contributing factor to the appearance of ASD. This systematic review article analyzes the results of the intervention using prebiotics (carrot powder, vitamin A, partially hydrolyzed guar gum, galactooligosaccharides, etc.), probiotics (mainly: Lactobacillus, Bifidobacterium, etc.) and transplantation of fecal microbiota in ASD children. In conclusion, the results of the initial studies suggest changes in ASD symptoms, gastro-intestinal symptoms and GM composition after the interventions. However, the results should be taken with caution because there are very few studies that analyze the efficacy of long-term treatments and the different combinations of them.
近年来，越来越多的研究关注肠道微生物群（GM）对自闭症谱系障碍（ASD）儿童的影响。有一个假说认为，通过所谓的微生物群-肠-脑轴，情绪状态和肠道微生物的丰度之间存在关系。从这个意义上说，肠道微生物失调可能是 ASD 出现的一个促成因素。本文系统地综述了使用益生元（胡萝卜粉、维生素 A、部分水解瓜尔胶、半乳糖寡糖等）、益生菌（主要是：乳酸菌、双歧杆菌等）和粪便微生物移植干预 ASD 儿童的研究结果。总之，初步研究结果表明，干预后 ASD 症状、胃肠症状和 GM 组成发生了变化。然而，由于很少有研究分析长期治疗及其不同组合的疗效，因此应谨慎对待这些结果。
