Faculty of Medicine, Charles University, 500 03 Hradec Kralove, Czech Republic.
Department of Psychiatry, University Hospital in Hradec Kralove, 500 03 Hradec Kralove, Czech Republic.
Nutrients. 2024 Jun 21;16(13):1988. doi: 10.3390/nu16131988.
The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associated with gut dysbiosis, indicating that modulation of gut microbiota in children with ASD may thus reduce the manifestation of ASD symptoms. The aim of this pilot study (prospective randomized, double-blinded, placebo-controlled) was to evaluate efficacy of the biological response modifier Juvenil in modulating the microbiome of children with ASD and, in particular, whether Juvenil is able to alleviate the symptoms of ASD. In total, 20 children with ASD and 12 neurotypical children were included in our study. Supplementation of ASD children lasted for three months. To confirm Juvenil's impact on the gut microbiome, stool samples were collected from all children and the microbiome's composition was analyzed. This pilot study demonstrated that the gut microbiome of ASD children differed significantly from that of healthy controls and was converted by Juvenil supplementation toward a more neurotypical microbiome that positively modulated children's autism symptoms.
自闭症谱系障碍（ASD）的病因和发病机制尚未完全阐明。目前尚无针对 ASD 的治疗方法可显著改善核心症状。然而，最近的研究表明，ASD 与肠道菌群失调有关，这表明调节 ASD 儿童的肠道微生物群可能会减轻 ASD 症状的表现。本研究（前瞻性随机、双盲、安慰剂对照）旨在评估生物反应调节剂 Juvenil 调节 ASD 儿童肠道微生物群的疗效，特别是 Juvenil 是否能够缓解 ASD 症状。共有 20 名 ASD 儿童和 12 名神经正常的儿童被纳入我们的研究。ASD 儿童的补充持续了三个月。为了证实 Juvenil 对肠道微生物群的影响，从所有儿童中收集粪便样本并分析其微生物群的组成。这项初步研究表明，ASD 儿童的肠道微生物群与健康对照组有显著差异，并通过 Juvenil 补充转化为更接近神经典型的微生物群，正向调节儿童的自闭症症状。
