Sharma Vikash, Tiwari Raj Kumar, Shukla Shiv Shankar, Pandey Ravindra Kumar
Columbia Institute of Pharmacy, Raipur, C.G., India.
J Pharmacopuncture. 2020 Jun 30;23(2):54-61. doi: 10.3831/KPI.2020.23.009.
Inflammation is an immune response of the human body but excessive inflammation is taken as a major factor in the development of many diseases including autoimmune disorders, cancer and nerve disorders etc. In this regards the need is to suppress the inflammatory response. Suppression of extra or imperfect inflammatory response is not a big deal provided there is an exact knowledge of particular target in the body. Recent advancements in Pharmacological aspect made the therapy with improved outcomes in number of patients. Anticytokine therapy might be one of the important and novel approaches for inflammation and Arthritis. This can be achieved only when we go through the pathophysiology of expression and identification of mediators. Let's take an example of cytokine like interleukins (IL), chemokines, interferons (INF), tumor necrosis factors (TNF-α), growth factors, and colony stimulating factors) release pathway which is a major signalling protein in inflammatory response. In the present study we have reviewed the recent pharmacological therapeutic advancement, inflammatory mediators, receptors, and major signalling pathways. Such information will not only provide the idea about the mechanism of action of Pharmaceuticals and molecular targets but also it provides a new aspect for drug designing and new corrective approaches in existing clinical medicines. This study will be a source of good information for the researchers working in the area of drug designing and molecular Pharmacology especially in anti-inflammatory and anti arthritic medicines for target based therapy.
炎症是人体的一种免疫反应，但过度炎症被视为包括自身免疫性疾病、癌症和神经紊乱等在内的多种疾病发展的主要因素。在这方面，需要抑制炎症反应。只要确切了解体内的特定靶点，抑制额外或不完善的炎症反应并非难事。药理学方面的最新进展使许多患者的治疗效果得到改善。抗细胞因子疗法可能是治疗炎症和关节炎的重要且新颖的方法之一。只有当我们深入了解炎症介质的表达病理生理学和识别机制时才能实现这一点。以细胞因子如白细胞介素（IL）、趋化因子、干扰素（INF）、肿瘤坏死因子（TNF-α）、生长因子和集落刺激因子的释放途径为例，它是炎症反应中的主要信号蛋白。在本研究中，我们综述了近期的药理学治疗进展、炎症介质、受体和主要信号通路。这些信息不仅能让我们了解药物的作用机制和分子靶点，还为药物设计和现有临床药物的新校正方法提供了新的思路。这项研究将为从事药物设计和分子药理学领域工作的研究人员，特别是从事基于靶点治疗的抗炎和抗关节炎药物研究的人员提供丰富的信息来源。
