Kim Chan Joong, Kim Bo Mi, Kim Cheon Suk, Baek Jung Yeon, Jung In Chan
Urban agriculture research Division, National Institute of Horticultural and Hebal science, Republic of Korea.
Department of Chemistry, Hanseo University, Seosan, Republic of Korea.
J Pharmacopuncture. 2020 Jun 30;23(2):79-87. doi: 10.3831/KPI.2020.23.012.
Ginsenosides found in ginseng, and the hydrolysates derived from their conversion, exhibit diverse pharmacological characteristics [1]. These have been shown to include anti-cancer, anti-angiogenic, and anti-metastatic effects, as well as being able to provide hepatic and neuroprotective effects, immunomodulation, vasodilation, promotion of insulin secretion, and antioxidant activity. Therefore, the purpose of this study was to examine how quickly the ginsenosides decompose and what kinds of degradation products are created under physicochemical processing conditions that don't involve toxic chemicals or other treatments that may be harmful.
The formation of ginsenoside-Rg2 and ginsenoside-Rg3 was examined. These demonstrated diverse pharmacological effects.
We also investigated physicochemical factors affecting their conversion. The heating temperatures and times yielding the highest concentration of ginsenosides (-Rb1, -Rb2, -Rc, -Rd, -Rf, -Rg1, and -Re) were examined. Additionally, the heating temperatures and rates of conversion of these ginsenosides into new 'ginseng saponins', were examined.
In conclusion, obtained provide us with effective technology to control the concentration of both ginsenosides and the downstream converted saponins (ginsenoside-Rg2, Rg3, Rg5, and Rk1 etc.), as well as identifying the processing conditions which enable an enrichment in concentration of these compounds.
人参中发现的人参皂苷及其转化产生的水解产物具有多种药理特性[1]。这些特性已被证明包括抗癌、抗血管生成和抗转移作用，以及能够提供肝脏和神经保护作用、免疫调节、血管舒张、促进胰岛素分泌和抗氧化活性。因此，本研究的目的是研究在不涉及有毒化学物质或其他可能有害处理的物理化学加工条件下，人参皂苷分解的速度有多快，以及会产生哪些降解产物。
研究了人参皂苷-Rg2和人参皂苷-Rg3的形成。这些人参皂苷表现出多种药理作用。
我们还研究了影响它们转化的物理化学因素。研究了产生最高浓度人参皂苷（-Rb1、-Rb2、-Rc、-Rd、-Rf、-Rg1和-Re）的加热温度和时间。此外，还研究了这些人参皂苷转化为新的“人参皂苷”的加热温度和转化率。
总之，研究结果为我们提供了有效技术，以控制人参皂苷和下游转化皂苷（人参皂苷-Rg2、Rg3、Rg5和Rk1等）的浓度，并确定能够富集这些化合物浓度的加工条件。
