新型冠状病毒肺炎中的血栓形成与凝血病：图文综述
Thrombosis and coagulopathy in COVID-19: An illustrated review.
作者信息
Levi Marcel, Hunt Beverley J
机构信息
Department of Medicine and Cardiometabolic Programme-NIHR UCLH/UCL BRC University College London Hospitals NHS Foundation Trust London UK.
Thrombosis & Haemophilia Centre Guys & St Thomas NHS Foundation Trust London UK.
出版信息
Res Pract Thromb Haemost. 2020 Jul 11;4(5):744-751. doi: 10.1002/rth2.12400. eCollection 2020 Jul.
Abstract
This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID-19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute-phase proteins, very high levels of D-dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID-19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).
摘要
本图文综述讨论了2019年冠状病毒病（COVID-19）重症患者出现的止血变化及其可能原因。我们探讨了炎症与凝血之间的相互作用，这种相互作用导致重症COVID-19患者出现高水平的急性期蛋白、极高水平的D-二聚体，以及无弥散性血管内凝血。重症COVID-19患者似乎有较高的静脉血栓栓塞发生率，而且在急性肺损伤中之前描述较少的是，有较高的肺免疫血栓形成发生率（炎症继发的血栓形成）。
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