Carrillo Miguel F, Kemper Deborah, Woods Leslie W, Carvallo Francisco R
Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), La Estanzuela, Colonia, Uruguay (Carrillo).
West Coast Equine Hospital, Somis, CA (Kemper).
J Vet Diagn Invest. 2020 Jul;32(4):621-625. doi: 10.1177/1040638720936251.
A 22-y-old American Quarter Horse gelding was presented with a history of chronic progressive respiratory problems and a diffuse pulmonary nodular pattern in thoracic radiographs. The horse was euthanized, and 4 formalin-fixed samples of lung were submitted for histopathology. There were multifocal areas of marked thickening of alveolar septa as a result of proliferation of myofibroblasts embedded in fibromyxoid matrix (interpreted as "Masson bodies"), focal areas of fibrosis, and numerous papillary projections of connective tissue into bronchioles. A diagnosis of organizing pneumonia was reached. No etiology was found for this lesion. It is important to consider causes of chronic interstitial pneumonia with fibrosis in horses other than equid herpesvirus 5, such as complicated viral or bacterial pneumonia or chronic toxicoses.
一匹22岁的美国夸特马公马因慢性进行性呼吸问题就诊，胸部X光片显示肺部弥漫性结节状影像。该马实施安乐死后，提交了4份经福尔马林固定的肺组织样本进行组织病理学检查。可见多灶性肺泡间隔显著增厚，这是由于肌成纤维细胞在纤维黏液样基质中增生（被解释为“马松小体”）、局灶性纤维化，以及结缔组织向细支气管的大量乳头状突起。诊断为机化性肺炎。未发现该病变的病因。除马疱疹病毒5外，还需考虑马匹慢性间质性肺炎伴纤维化的其他病因，如复杂性病毒或细菌性肺炎或慢性中毒。
