Bartolucci M, Galluzzi F, Sanchioni G, Aureli G
Laboratorio di analisi cliniche e microbiologiche, Ospedale s. Salvatore, Pesaro.
Quad Sclavo Diagn. 1988 Jan-Dec;24(1-4):203-12.
The antibacterial activity in vitro of Imipenem (N-formimidoyl-thienamycin) was studied on 237 recently-isolated nosocomial bacterial strains and compared with Aztreonam, Cefotaxime, Ceftazidime, Ceftriaxone, Piperacillin, Amikacin and Netilmicin through the determination of susceptibility by the Kirby-Bauer method. Taking into account that 65% bacterial strains, out of the examined ones, came from antibiotic high-pressure departments (45% from bone-marrow transplanted patients in the Hematological Department and 20% from Intensive Care Unit patients), the results obtained in vitro show an activity of Imipenem on Gram-negative bacteria as much as a 92.7% susceptibility and a 75.7% on Gram-positive bacteria; when compared with the activity of the other antibiotics, Imipenem shows a really excellent activity.
对237株近期分离的医院内感染菌株研究了亚胺培南（N-甲酰亚胺基硫霉素）的体外抗菌活性，并通过Kirby-Bauer法测定敏感性，与氨曲南、头孢噻肟、头孢他啶、头孢曲松、哌拉西林、阿米卡星和奈替米星进行比较。鉴于在所检测的菌株中，65%来自抗生素使用频繁科室（45%来自血液科骨髓移植患者，20%来自重症监护病房患者），体外获得的结果显示亚胺培南对革兰氏阴性菌的活性可达92.7%的敏感性，对革兰氏阳性菌为75.7%；与其他抗生素的活性相比，亚胺培南显示出非常优异的活性。
