Duperret Michael E
Independent Researcher, Tucson, Arizona, USA
BMJ Case Rep. 2020 Jul 20;13(7):e235331. doi: 10.1136/bcr-2020-235331.
A 45-year-old man presented with acute sinusitis. He was treated with a 10-day course of trimethoprim/sulfamethoxazole, and a subsequent 14-day course of amoxicillin-clavulanate with no improvement in symptoms. Culture of purulent nasal secretions revealed the rare enterobacter The patient had complete resolution of his symptoms after a 14-day course of gentamicin/dexamethasone nasal rinses. Emerging pathogens have been a timeless concern for physicians, as witnessed by the current SARS-CoV-2 outbreak. has been reported to cause human infection only a dozen times since its discovery, all in severely compromised patients. This is the first documented case of sinusitis reported with and may portend a rising prevalence of disease burden in the general population. This case demonstrates the necessity of obtaining cultures when standard antibiotics result in treatment failure.
一名45岁男性因急性鼻窦炎就诊。他接受了为期10天的甲氧苄啶/磺胺甲恶唑治疗，随后又接受了为期14天的阿莫西林-克拉维酸治疗，但症状并无改善。脓性鼻分泌物培养显示为罕见的肠杆菌。在接受了为期14天的庆大霉素/地塞米松鼻腔冲洗后，患者症状完全缓解。新出现的病原体一直是医生们长期关注的问题，当前的SARS-CoV-2疫情就是例证。自发现以来，据报道仅在严重免疫功能低下的患者中导致人类感染过12次。这是首例有记录的由[此处原文缺失病原体名称]引起的鼻窦炎病例，可能预示着普通人群中疾病负担的患病率上升。该病例表明，当标准抗生素治疗失败时，进行培养的必要性。
