School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.
School of Biomedical Sciences, The University of Queensland, Woolloongabba, Australia.
Elife. 2020 Jul 22;9:e56907. doi: 10.7554/eLife.56907.
Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood. Here, the effects of high glucose levels on influenza severity were investigated using an model of the pulmonary epithelial-endothelial barrier as well as an murine model of type II diabetes. we show that high glucose conditions prior to IAV infection increased virus-induced barrier damage. This was associated with an increased pro-inflammatory response in endothelial cells and the subsequent damage of the epithelial junctional complex. These results were subsequently validated . This study provides the first evidence that hyperglycaemia may increase influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema. These data suggest that maintaining long-term glucose control in individuals with diabetes is paramount in reducing the morbidity and mortality associated with influenza virus infections.
糖尿病是严重流感病毒感染的已知易感因素。然而，导致这种易感性的机制仍不完全清楚。在这里，我们使用肺上皮-内皮屏障模型以及 II 型糖尿病小鼠模型，研究了高血糖水平对流感严重程度的影响。结果表明，在感染 IAV 之前的高血糖条件增加了病毒诱导的屏障损伤。这与内皮细胞中促炎反应的增加以及随后的上皮连接复合体损伤有关。这些结果随后得到了验证。这项研究首次提供了证据表明，高血糖可能通过损伤肺上皮-内皮屏障和增加肺水肿来加重流感的严重程度。这些数据表明，在糖尿病患者中维持长期血糖控制对于降低流感病毒感染相关的发病率和死亡率至关重要。
