Leumit HMO, Tel-Aviv, Israel.
Tel Aviv University, Tel Aviv, Israel.
J Atten Disord. 2021 Nov;25(13):1791-1800. doi: 10.1177/1087054720940392. Epub 2020 Jul 23.
Although the short-term neurological complications of spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD.
This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5-18 years who underwent stool culture prior to the age of 3 years.
Of 52,761 children with a stool culture examined, 5,269 (9.98%) had -positive results. The rate of ADHD was 10.6% and 8.6% among children with positive and negative stool cultures, respectively ( < .001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13-1.29, < .001). The younger the child was during gastroenteritis, the higher was the association with ADHD ( < .001).
Early childhood shigellosis is associated with an increased rate of long-term ADHD.
虽然志贺氏菌属的短期神经并发症已有详细描述，但尚未研究其潜在的神经精神结局。我们研究了儿童期志贺氏菌感染与随后发生多动症之间的关联。
这是一项回顾性基于人群的队列研究。我们利用一个大型医疗保健组织数据库，调查了 3 岁前进行粪便培养的 5-18 岁儿童中多动症的患病率。
在 52761 名接受粪便培养的儿童中，5269 名（9.98%）的检测结果为阳性。阳性粪便培养组和阴性粪便培养组的 ADHD 发生率分别为 10.6%和 8.6%（<0.001）。在控制了性别和社会经济地位后，ADHD 的调整后优势比为 1.21（95%CI 1.13-1.29，<0.001）。儿童患肠胃炎时年龄越小，与 ADHD 的相关性越高（<0.001）。
儿童期志贺氏菌感染与长期 ADHD 发生率增加有关。
