Kimoto Takumi, Suzuki Kou, Fukuda Takashi, Emoto Akira
Graduate School of Science and Engineering, Doshisha University, 1-3 Tatara-Miyakodani, Kyotanabe, Kyoto 610-0321, Japan.
Sensing System Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Biomicrofluidics. 2020 Jul 10;14(4):044104. doi: 10.1063/5.0014956. eCollection 2020 Jul.
In this paper, we propose a novel approach to fabricate fluidic chips. The method utilizes molecular cross-diffusion, induced by photopolymerization under ultraviolet (UV) irradiation in a channel pattern, to form the channel structures. During channel structure formation, the photopolymer layer still contains many uncured molecules. Subsequently, a top substrate is attached to the channel structure under adequate pressure, and the entire chip is homogenously irradiated by UV light. Immediately thereafter, a sufficiently sealed fluidic chip is formed. Using this fabrication process, the channel pattern of a chip can be designed quickly by a computer as binary images, and practical chips can be produced on demand at a benchtop, instead of awaiting production in specialized factories.
在本文中，我们提出了一种制造微流控芯片的新方法。该方法利用在紫外（UV）照射下，通道图案中的光聚合反应诱导的分子交叉扩散来形成通道结构。在通道结构形成过程中，光聚合物层仍包含许多未固化的分子。随后，在适当压力下将顶部基板附着到通道结构上，并用紫外光对整个芯片进行均匀照射。此后立即形成一个密封良好的微流控芯片。利用这种制造工艺，芯片的通道图案可以通过计算机快速设计为二进制图像，并且可以在实验台上按需生产实用芯片，而无需等待在专门工厂生产。
