Khan Asadullah, Haroon Muhammad, Bashir Farhan, Din Zia Ud
Asadullah Khan, FCPS (Medicine)., Division of Rheumatology, Fatima Memorial Hospital, Lahore, Pakistan.
Muhammad Haroon, FRSM, FFSEM, FACR, FRCP., Division of Rheumatology, Fatima Memorial Hospital, Lahore, Pakistan.
Pak J Med Sci. 2020 Jul-Aug;36(5):1005-1010. doi: 10.12669/pjms.36.5.1916.
To analyze the clinical manifestation of patients with Behcet's disease, and performance of different classification criteria of Behcet's disease in our population.
It was a retrospective analysis of all Behcet's disease patients attending Department of Rheumatology at Fatima Memorial Hospital, Lahore, Pakistan from April 2019 to July 2019. We performed a comprehensive clinical evaluation of patients with Behcet's disease, with focus on patients' age, gender and different clinical manifestations.
A consecutive cohort of 20 patients was studied. All patients met the International Criteria of Behcet's Disease criteria, and 18 out of 20 patients also met International Study Group criteria. Mean age of the cohort was 33.5±10.4 years and 45% was female (male to female ratio of 1:1.2). Around 90% of cohort had recurrent oral and genital ulcers. Ocular involvement was present in 80% patients, while Joint manifestations were present in 75% of patients. Cutaneous, neurological (both central and peripheral nervous system involvement), and GIT symptoms were present in 50%, 30%, and 15% of patients, consecutively. Joint pain and eye symptoms were major initial symptoms in males, while eye symptoms and neurological symptoms were more common in female patients at disease onset. Reaching border line significance, Cutaneous(p-value=0.479), ocular(p-value=0.61), and GIT involvement(p-value=0.59) were more prevalent in males while neurological involvement (p-value=0.336) in females.
Behcet's disease occurs commonly in middle age population with equal male to female ratio, with mucocutaneus aphthosis, ocular disease and joint pains being common manifestation. Gastrointestinal symptoms are more common in males while neurological symptoms in females.
分析白塞病患者的临床表现，以及不同白塞病分类标准在我国人群中的应用情况。
对2019年4月至2019年7月在巴基斯坦拉合尔法蒂玛纪念医院风湿科就诊的所有白塞病患者进行回顾性分析。我们对白塞病患者进行了全面的临床评估，重点关注患者的年龄、性别和不同的临床表现。
共研究了连续的20例患者。所有患者均符合白塞病国际标准，20例患者中有18例也符合国际研究组标准。该队列的平均年龄为33.5±10.4岁，45%为女性（男女比例为1:1.2）。约90%的队列患者有复发性口腔溃疡和生殖器溃疡。80%的患者有眼部受累，75%的患者有关节表现。皮肤、神经（中枢和周围神经系统均受累）和胃肠道症状分别出现在50%、30%和15%的患者中。关节疼痛和眼部症状是男性的主要初始症状，而眼部症状和神经症状在女性患者发病时更为常见。皮肤受累（p值=0.479）、眼部受累（p值=0.61）和胃肠道受累（p值=0.59）在男性中更为普遍，而神经受累（p值=0.336）在女性中更为普遍，差异接近显著水平。
白塞病常见于中年人群，男女比例相等，黏膜皮肤口疮、眼部疾病和关节疼痛是常见表现。胃肠道症状在男性中更常见，而神经症状在女性中更常见。
