Heath Laura, Yates Sharon, Carey Matthew, Miller Mary
Oxford University Hospitals NHS Foundation Trust, Palliative Care Sir Michael Sobell House Hospice, Oxford, UK.
Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Oxford, UK.
Am J Hosp Palliat Care. 2020 Nov;37(11):988-991. doi: 10.1177/1049909120943577. Epub 2020 Jul 24.
A vital component of the coronavirus response is care of the dying COVID-19 patient. We document the demographics, symptoms experienced, medications required, effectiveness observed, and challenges to high-quality holistic palliative care in 31 patients. This will aid colleagues in primary and secondary care settings anticipate common symptoms and formulate management plans.
A retrospective survey was conducted of patients referred to the hospital palliative care service in a tertiary hospital, south east of England between March 21 and April 26, 2020. Patients included had a confirmed laboratory diagnosis of COVID-19 via reverse transcription polymerase chain reaction nasopharyngeal swab for SARS-Cov-2 or radiological evidence of COVID-19.
The thirty-one patients included were predominantly male (77%), elderly (median [interquartile range]: 84 [76-89]), and had multiple (4 [3-5]) comorbidities. Referral was made in the last 2 [1-3] days of life. Common symptoms were breathlessness (84%) and delirium (77%). Fifty-eight percent of patients received at least 1 "as required" dose of an opioid or midazolam in the 24 hours before death. Sixty percent of patients needed a continuous subcutaneous infusion and the median morphine dose was 10 mg S/C per 24 hours and midazolam 10 mg S/C per 24 hours. Nineteen percent of our cohort had a loved one or relative present when dying.
We provide additional data to the internationally reported pool examining death arising from infection with SARS-CoV-19. The majority of patients had symptoms controlled with low doses of morphine and midazolam, and death was rapid. The impact of low visitation during dying needs exploring.
应对冠状病毒的一个关键组成部分是对临终的新冠病毒患者的护理。我们记录了31例患者的人口统计学特征、经历的症状、所需药物、观察到的疗效以及高质量整体姑息治疗面临的挑战。这将有助于初级和二级医疗机构的同事预测常见症状并制定管理计划。
对2020年3月21日至4月26日期间转诊至英格兰东南部一家三级医院姑息治疗服务部门的患者进行了回顾性调查。纳入的患者通过针对严重急性呼吸综合征冠状病毒2的逆转录聚合酶链反应鼻咽拭子确诊为新冠病毒感染,或有新冠病毒感染的影像学证据。
纳入的31例患者主要为男性(77%),年龄较大(中位数[四分位间距]:84[76 - 89]岁),且有多种(4[3 - 5]种)合并症。转诊发生在生命的最后2[1 - 3]天。常见症状为呼吸困难(84%)和谵妄(77%)。58%的患者在死亡前24小时内至少接受了1剂“按需”使用的阿片类药物或咪达唑仑。60%的患者需要持续皮下输注,吗啡的中位剂量为每24小时10毫克皮下注射,咪达唑仑为每24小时10毫克皮下注射。19%的患者在临终时有亲人或亲属在场。
我们为国际上报告的关于严重急性呼吸综合征冠状病毒2感染导致死亡的研究提供了更多数据。大多数患者通过低剂量吗啡和咪达唑仑控制症状,且死亡迅速。临终时探视率低的影响有待探讨。