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A Dual-Center Observational Review of Hospital-Based Palliative Care in Patients Dying With COVID-19.一项针对新冠病毒病临终患者的医院姑息治疗的双中心观察性综述
J Pain Symptom Manage. 2020 Aug;60(2):e75-e78. doi: 10.1016/j.jpainsymman.2020.04.031. Epub 2020 May 6.
2
The key role of palliative care in response to the COVID-19 tsunami of suffering.姑息治疗在应对新冠疫情苦难海啸中的关键作用。
Lancet. 2020 May 9;395(10235):1467-1469. doi: 10.1016/S0140-6736(20)30964-8. Epub 2020 Apr 22.
3
Characteristics and Palliative Care Needs of COVID-19 Patients Receiving Comfort-Directed Care.接受姑息治疗的新冠病毒肺炎患者的特征及姑息治疗需求
J Am Geriatr Soc. 2020 Jun;68(6):1162-1164. doi: 10.1111/jgs.16507. Epub 2020 May 6.
4
Characteristics, Symptom Management, and Outcomes of 101 Patients With COVID-19 Referred for Hospital Palliative Care.101 例因 COVID-19 转诊至医院姑息治疗的患者的特征、症状管理和结局。
J Pain Symptom Manage. 2020 Jul;60(1):e77-e81. doi: 10.1016/j.jpainsymman.2020.04.015. Epub 2020 Apr 20.
5
Palliative care and the COVID-19 pandemic.姑息治疗与新冠疫情
Lancet. 2020 Apr 11;395(10231):1168. doi: 10.1016/S0140-6736(20)30822-9.
6
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations.2019 冠状病毒病(COVID-19)的重症监护管理:挑战与建议。
Lancet Respir Med. 2020 May;8(5):506-517. doi: 10.1016/S2213-2600(20)30161-2. Epub 2020 Apr 6.
7
Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.意大利新冠肺炎死亡患者的病死率及特征
JAMA. 2020 May 12;323(18):1775-1776. doi: 10.1001/jama.2020.4683.
8
COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.COVID-19 患者的临床特征、出院率和死亡率的荟萃分析。
J Med Virol. 2020 Jun;92(6):577-583. doi: 10.1002/jmv.25757. Epub 2020 Mar 23.
9
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.中国2019年冠状病毒病(COVID-19)疫情的特征及重要经验教训:来自中国疾病预防控制中心72314例病例报告的总结
JAMA. 2020 Apr 7;323(13):1239-1242. doi: 10.1001/jama.2020.2648.

新冠疫情期间的姑息治疗:数据与亲人探访

Palliative Care During COVID-19: Data and Visits From Loved Ones.

作者信息

Heath Laura, Yates Sharon, Carey Matthew, Miller Mary

机构信息

Oxford University Hospitals NHS Foundation Trust, Palliative Care Sir Michael Sobell House Hospice, Oxford, UK.

Nuffield Department of Primary Care Health Sciences, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Oxford, UK.

出版信息

Am J Hosp Palliat Care. 2020 Nov;37(11):988-991. doi: 10.1177/1049909120943577. Epub 2020 Jul 24.

DOI:10.1177/1049909120943577
PMID:32705889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7747028/
Abstract

OBJECTIVES

A vital component of the coronavirus response is care of the dying COVID-19 patient. We document the demographics, symptoms experienced, medications required, effectiveness observed, and challenges to high-quality holistic palliative care in 31 patients. This will aid colleagues in primary and secondary care settings anticipate common symptoms and formulate management plans.

METHODS

A retrospective survey was conducted of patients referred to the hospital palliative care service in a tertiary hospital, south east of England between March 21 and April 26, 2020. Patients included had a confirmed laboratory diagnosis of COVID-19 via reverse transcription polymerase chain reaction nasopharyngeal swab for SARS-Cov-2 or radiological evidence of COVID-19.

RESULTS

The thirty-one patients included were predominantly male (77%), elderly (median [interquartile range]: 84 [76-89]), and had multiple (4 [3-5]) comorbidities. Referral was made in the last 2 [1-3] days of life. Common symptoms were breathlessness (84%) and delirium (77%). Fifty-eight percent of patients received at least 1 "as required" dose of an opioid or midazolam in the 24 hours before death. Sixty percent of patients needed a continuous subcutaneous infusion and the median morphine dose was 10 mg S/C per 24 hours and midazolam 10 mg S/C per 24 hours. Nineteen percent of our cohort had a loved one or relative present when dying.

CONCLUSION

We provide additional data to the internationally reported pool examining death arising from infection with SARS-CoV-19. The majority of patients had symptoms controlled with low doses of morphine and midazolam, and death was rapid. The impact of low visitation during dying needs exploring.

摘要

目的

应对冠状病毒的一个关键组成部分是对临终的新冠病毒患者的护理。我们记录了31例患者的人口统计学特征、经历的症状、所需药物、观察到的疗效以及高质量整体姑息治疗面临的挑战。这将有助于初级和二级医疗机构的同事预测常见症状并制定管理计划。

方法

对2020年3月21日至4月26日期间转诊至英格兰东南部一家三级医院姑息治疗服务部门的患者进行了回顾性调查。纳入的患者通过针对严重急性呼吸综合征冠状病毒2的逆转录聚合酶链反应鼻咽拭子确诊为新冠病毒感染,或有新冠病毒感染的影像学证据。

结果

纳入的31例患者主要为男性(77%),年龄较大(中位数[四分位间距]:84[76 - 89]岁),且有多种(4[3 - 5]种)合并症。转诊发生在生命的最后2[1 - 3]天。常见症状为呼吸困难(84%)和谵妄(77%)。58%的患者在死亡前24小时内至少接受了1剂“按需”使用的阿片类药物或咪达唑仑。60%的患者需要持续皮下输注,吗啡的中位剂量为每24小时10毫克皮下注射,咪达唑仑为每24小时10毫克皮下注射。19%的患者在临终时有亲人或亲属在场。

结论

我们为国际上报告的关于严重急性呼吸综合征冠状病毒2感染导致死亡的研究提供了更多数据。大多数患者通过低剂量吗啡和咪达唑仑控制症状,且死亡迅速。临终时探视率低的影响有待探讨。