Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland.
Int J Mol Sci. 2020 Jul 19;21(14):5105. doi: 10.3390/ijms21145105.
The skin is an important organ that acts as a physical barrier to the outer environment. It is rich in immune cells such as keratinocytes, Langerhans cells, mast cells, and T cells, which provide the first line of defense mechanisms against numerous pathogens by activating both the innate and adaptive response. Cutaneous immunological processes may be stimulated or suppressed by numerous plant extracts via their immunomodulatory properties. Several plants are rich in bioactive molecules; many of these exert antimicrobial, antiviral, and antifungal effects. The present study describes the impact of plant extracts on the modulation of skin immunity, and their antimicrobial effects against selected skin invaders. Plant products remain valuable counterparts to modern pharmaceuticals and may be used to alleviate numerous skin disorders, including infected wounds, herpes, and tineas.
皮肤是一种重要的器官，作为对外界环境的物理屏障。它富含免疫细胞，如角质形成细胞、朗格汉斯细胞、肥大细胞和 T 细胞，这些细胞通过激活先天和适应性反应，为抵抗多种病原体提供第一道防御机制。许多植物提取物具有免疫调节特性，可以刺激或抑制皮肤的免疫过程。几种植物富含生物活性分子；其中许多具有抗微生物、抗病毒和抗真菌作用。本研究描述了植物提取物对皮肤免疫调节的影响及其对选定皮肤病原体的抗菌作用。植物产品仍然是现代药物的宝贵替代品，可用于缓解许多皮肤疾病，包括感染性伤口、疱疹和癣。
