Faculty of Chemistry & Environment Sciences, Guangdong Ocean University, Zhanjiang 524088, China.
Mar Drugs. 2020 Jul 22;18(8):376. doi: 10.3390/md18080376.
Fucoidan-a marine natural active polysaccharide derived from brown algae with a variety of medicinal activities and low toxicity-has been used as clinical drug for renal diseases for nearly 20 years. The pharmacological mechanism of fucoidan has been well-investigated, based on target molecules and downstream signaling pathways. This review summarizes some important molecular targets of fucoidan and its related biologic activities, including scavenger receptor (SR), Toll-like receptors (TLRs), C-type lectin (CLEC) and some newly found target molecules, which may be beneficial for further understanding the pharmacological mechanism of fucoidan and discovering its new functions, as well as developing related clinical or adjuvant drugs and functional preparations.
岩藻聚糖硫酸酯是一种从褐藻中提取的天然海洋活性多糖，具有多种药用活性且毒性低，近 20 年来已被用作治疗肾病的临床药物。岩藻聚糖硫酸酯的药理学机制已得到充分研究，基于靶分子和下游信号通路。本文综述了岩藻聚糖硫酸酯的一些重要的分子靶标及其相关的生物学活性，包括清道夫受体（SR）、Toll 样受体（TLRs）、C 型凝集素（CLEC）和一些新发现的靶标分子，这可能有助于进一步了解岩藻聚糖硫酸酯的药理学机制和发现其新的功能，并开发相关的临床或辅助药物和功能制剂。
