Needle David B, Marr Jacqueline L, Park Cooper J, Andam Cheryl P, Wise Annabel G, Maes Roger K, Wilkes Rebecca P, Anis Eman A, Sidor Inga F, Agnew Dalen, Ellis Julie C, Tate Patrick, Mathewson Abigail, Benton Christopher, Gibson Robert
New Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH 03824, USA.
Animal Health Diagnostic Center, Cornell University, Ithaca, NY 14850, USA.
Pathogens. 2020 Jul 21;9(7):591. doi: 10.3390/pathogens9070591.
One free-ranging Gray fox () underwent autopsy following neurologic disease, with findings including morbilliviral inclusions and associated lesions in numerous tissues, adenoviral intranuclear inclusions in bronchial epithelial cells, and septic pleuropneumonia, hepatitis, splenitis, and meningoencephalitis. Molecular diagnostics on fresh lung identified a strain within a distinct clade of canine distemper that is currently unique to wildlife in New England, as well as the emerging multi-host viral pathogen skunk adenovirus-1. Bacterial culture of fresh liver resulted in a pure growth of , with whole genome sequencing indicating that the isolate had a vast array of antimicrobial resistance and virulence-associated genes. One year later, a second fox was euthanized for inappropriate behavior in a residential area, and diagnostic workup revealed canine distemper and septic , with the former closely related to the distemper virus found in the previous fox and the latter divergent from the from the previous fox.
一只自由放养的灰狐在出现神经疾病后进行了尸检，发现包括在许多组织中的麻疹病毒包涵体及相关病变、支气管上皮细胞中的腺病毒核内包涵体，以及败血性胸膜肺炎、肝炎、脾炎和脑膜脑炎。对新鲜肺组织进行的分子诊断鉴定出一种属于犬瘟热独特分支的毒株，该毒株目前在新英格兰野生动物中是独一无二的，同时还鉴定出新兴的多宿主病毒病原体臭鼬腺病毒-1。新鲜肝脏的细菌培养产生了纯的 生长物，全基因组测序表明该分离株具有大量抗菌抗性和毒力相关基因。一年后，第二只狐狸因在居民区行为不当而被安乐死，诊断检查发现患有犬瘟热和败血性 ，前者与之前狐狸中发现的犬瘟热病毒密切相关，后者与之前狐狸中的 不同。
