Department of Plant and Microbial Biology, North Carolina State University , Raleigh, North Carolina, USA.
Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University , Raleigh, North Carolina, USA.
Appl Environ Microbiol. 2023 Nov 29;89(11):e0120523. doi: 10.1128/aem.01205-23. Epub 2023 Oct 27.
causes severe foodborne illness and is the only human pathogen in the genus . Previous surveys of AMR in focused on clinical sources and food or food processing environments, with AMR in strains from wildlife and other natural ecosystems remaining under-explored. We analyzed 185 sequenced strains from wild black bears () from the United States, including 158 and 27 . and , respectively. Tetracycline resistance was the most prevalent resistance trait. In . monocytogenes, it was encountered exclusively in serotype 4b strains with the novel Tn-like element Tn. In contrast, three distinct, novel tetracycline resistance elements (Tn, , and Tn) were identified in . Interestingly, was identical to elements in from a major foodborne outbreak in the United States in 2011. The findings suggest the importance of wildlife and non-pathogenic species as reservoir for resistance elements in .
导致严重的食源性疾病，是该属中唯一的人类病原体。先前针对 在 中的抗药性的调查主要集中在临床来源、食物或食物加工环境，而野生动物和其他自然生态系统中的 菌株的抗药性仍未得到充分探索。我们分析了来自美国的 185 株野生黑熊（）的已测序菌株，其中包括 158 株 和 27 株 。四环素耐药性是最普遍的耐药特征。在 中，它仅在新型 Tn 样元件 Tn 存在于血清型 4b 菌株中。相比之下，在 中鉴定出三个不同的新型四环素耐药元件（Tn、Tn 和 Tn）。有趣的是，Tn 在 2011 年美国一起重大食源性暴发的 中与元件相同。这些发现表明了野生动物和非致病性 物种作为 中耐药元件的储库的重要性。
