儿童和成人鼻内血管紧张素转换酶 2 的基因表达。
Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults.
机构信息
Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
出版信息
JAMA. 2020 Jun 16;323(23):2427-2429. doi: 10.1001/jama.2020.8707.
Abstract
This study compares angiotensin-converting enzyme 2 () gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.
摘要
这项研究比较了血管紧张素转换酶 2 () 基因表达，该基因与 SARS-CoV-2 细胞进入有关，比较了儿童和成人鼻腔上皮中的表达情况。
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本文引用的文献
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Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020.2019 年冠状病毒病在儿童中的情况-美国，2020 年 2 月 12 日至 4 月 2 日。
MMWR Morb Mortal Wkly Rep. 2020 Apr 10;69(14):422-426. doi: 10.15585/mmwr.mm6914e4.
2
Epidemiology of COVID-19 Among Children in China.中国儿童 COVID-19 流行病学。
Pediatrics. 2020 Jun;145(6). doi: 10.1542/peds.2020-0702. Epub 2020 Mar 16.
3
Integrative study of the upper and lower airway microbiome and transcriptome in asthma.哮喘患者上下呼吸道微生物组和转录组的综合研究
JCI Insight. 2020 Mar 12;5(5):133707. doi: 10.1172/jci.insight.133707.
4
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
5
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JAMA. 2020 Apr 7;323(13):1239-1242. doi: 10.1001/jama.2020.2648.
6
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.急性呼吸窘迫综合征中肺部宿主反应的年龄依赖性差异：一项前瞻性观察队列研究。
Ann Intensive Care. 2019 May 14;9(1):55. doi: 10.1186/s13613-019-0529-4.
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