Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania; and
Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.
J Nucl Med Technol. 2020 Dec;48(4):331-335. doi: 10.2967/jnmt.120.247080. Epub 2020 Jul 24.
We report our PET/MRI experience from a pilot study that compared the diagnostic performance of F-FDG PET/MRI versus PET/CT in staging of cervical cancer. Six adults with newly diagnosed cervical cancer underwent a single F-FDG injection with a dual-imaging protocol: standard-of-care PET/CT followed by research PET/MRI. The diagnostic interpretation and SUV for the 2 modalities were compared. Both modalities detected all primary tumors (median size, 3.9 cm) and all 4 metastases present in 2 of the 6 patients (median size, 0.9 cm). PET/MRI provided greater diagnostic confidence than PET/CT and upstaged the disease in 4 patients. On the basis of the imaging findings alone, the additional information from PET/MRI would have led to a change in clinical management in 3 of 6 patients. The primary lesion showed a median SUV of 12.8 on PET/CT and 18.2 on PET/MRI ( = 0.03). SUVs, however, correlated strongly between the 2 modalities (ρ = 0.96, < 0.001). Our pilot study supports the notion that PET/MRI has the potential to impact clinical decisions and treatment strategies in women with cervical cancer. Further studies are, however, warranted to define the value that PET/MRI adds to PET/CT.
我们报告了一项试点研究的 PET/MRI 经验，该研究比较了 F-FDG PET/MRI 与 PET/CT 在宫颈癌分期中的诊断性能。6 名新诊断为宫颈癌的成年人接受了单次 F-FDG 注射，采用双成像方案：标准护理 PET/CT 后进行研究性 PET/MRI。比较了这两种方式的诊断解读和 SUV。两种方式均检测到了所有 6 名患者中的所有原发性肿瘤（中位大小为 3.9 厘米）和 4 名患者中的所有 4 个转移灶（中位大小为 0.9 厘米）。与 PET/CT 相比，PET/MRI 提供了更高的诊断信心，并在 4 名患者中进行了疾病升级分期。仅根据影像学发现，在 6 名患者中的 3 名中，PET/MRI 的额外信息将导致临床管理的改变。原发性病变在 PET/CT 上的 SUV 中位数为 12.8，在 PET/MRI 上为 18.2（=0.03）。然而，SUV 在两种方式之间具有很强的相关性（ρ=0.96，<0.001）。我们的试点研究支持 PET/MRI 有可能影响宫颈癌女性的临床决策和治疗策略的观点。然而，需要进一步的研究来确定 PET/MRI 为 PET/CT 增加的价值。
