Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo-si, Republic of Korea.
Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Republic of Korea.
Clin Respir J. 2020 Nov;14(11):1018-1024. doi: 10.1111/crj.13235. Epub 2020 Aug 13.
Poor sleep quality in patients with chronic obstructive pulmonary disease (COPD) has been associated with poor health outcomes. However, there is a lack of research on factors associated with sleep disturbance in patients with COPD.
We investigated patterns of sleep disturbance and factors associated with sleep impairment in patients with COPD.
This was a prospective, multicenter cross-sectional study enrolling a sample of 245 COPD subjects. All patients completed the patient-reported measure, the COPD and Asthma Sleep Impact Scale (CASIS) to assess sleep impairment. The St. George's Respiratory Questionnaire (SGRQ), the 36-item Short-Form health survey (SF-36), Hospital Anxiety and Depression Scale (HADS), and the COPD Self-Efficacy Scale (CSES) were utilized to assess health-related quality of life (HRQL), anxiety/depression and self-efficacy, respectively.
About 35.1% of the patients reported that they had a bad night's sleep. Univariate analysis showed that the CASIS total score was significantly correlated with the modified Medical Research Council dyspnea scale, SGRQ total score, SF-36 PCS, SF-36 MCS, HADS-A, HADS-D and CSES (all P < 0.05). In a multivariate analysis, SGRQ total (r = 0.19, P = 0.006), SF-36 PCS (r = 0.14, P = 0.037), HADS-D (r = 0.24, P ≤ 0.001), and CSES(r = -0.12, P = 0.010) were independently associated with the CASIS score.
In this study, 35% of clinically stable patients with COPD reported poor sleep quality. Depression, poorer HRQL and self-efficacy were significantly associated with sleep disturbance in patients with COPD.
慢性阻塞性肺疾病（COPD）患者的睡眠质量差与健康状况不佳有关。然而，目前关于 COPD 患者睡眠障碍相关因素的研究还比较缺乏。
我们调查了 COPD 患者睡眠障碍的模式和与睡眠障碍相关的因素。
这是一项前瞻性、多中心的横断面研究，纳入了 245 名 COPD 患者。所有患者均完成了患者报告的测量工具，COPD 和哮喘睡眠影响量表（CASIS），以评估睡眠障碍。圣乔治呼吸问卷（SGRQ）、36 项简短健康调查问卷（SF-36）、医院焦虑抑郁量表（HADS）和 COPD 自我效能量表（CSES）分别用于评估健康相关生活质量（HRQL）、焦虑/抑郁和自我效能。
约 35.1%的患者报告说他们晚上睡眠质量差。单因素分析显示，CASIS 总分与改良的医学研究理事会呼吸困难量表、SGRQ 总分、SF-36 PCS、SF-36 MCS、HADS-A、HADS-D 和 CSES 均显著相关（均 P<0.05）。在多因素分析中，SGRQ 总分（r=0.19，P=0.006）、SF-36 PCS（r=0.14，P=0.037）、HADS-D（r=0.24，P ≤ 0.001）和 CSES（r=-0.12，P=0.010）与 CASIS 评分独立相关。
在这项研究中，35%的临床稳定 COPD 患者报告睡眠质量差。抑郁、较差的 HRQL 和自我效能与 COPD 患者的睡眠障碍显著相关。
