Yu Hong-Ren, Sheen Jiunn-Ming, Tiao Mao-Meng, Tain You-Lin, Chen Chih-Cheng, Lin I-Chun, Lai Yun-Ju, Tsai Ching-Chou, Lin Yu-Ju, Tsai Ching-Chang, Chang Kow-Aung, Huang Li-Tung
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University,, Kaohsiung, Taiwan.
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
Mol Nutr Food Res. 2019 Jul;63(13):e1801385. doi: 10.1002/mnfr.201801385. Epub 2019 Apr 29.
Prenatal high-fat (HF) and postnatal HF diet are both associated with obesity and metabolic disturbances in adults. Leptin resistance induced by obesity limits its biological effects. The anti-obesity mechanism of resveratrol in visceral adiposity is investigated here.
During mating and lactation, Sprague-Dawley dams are fed either control or a HF diet. Subsequently, the offspring are fed chow or an HF diet. A fifth group that received maternal/postnatal HF diet and resveratrol after weaning (HHR) is used to study the effects of resveratrol treatment. Resveratrol treatment alleviates adiposity programed by maternal and postnatal HF diet by decreasing feed intake or inducing metabolic changes. Resveratrol treatment is also found to ameliorate the decrease in SIRT1 abundance observed in retroperitoneal adipose tissue, programed by maternal and postnatal HF diet. Moreover, resveratrol therapy decreases plasma leptin level and increases leptin receptor expression in retroperitoneal adipose tissue through DNA methylation modification.
These results suggest that resveratrol can alleviate peripheral leptin resistance programed by the combined effect of prenatal and postnatal HF diet through epigenetic regulation of genes coding leptin and its receptor. It provides insights into a novel mechanism explaining the beneficial effects of resveratrol in obesity management.
产前高脂（HF）饮食和产后HF饮食均与成年人肥胖及代谢紊乱相关。肥胖诱导的瘦素抵抗会限制其生物学效应。本文研究白藜芦醇在内脏肥胖中的抗肥胖机制。
在交配和哺乳期，给斯普拉格-道利母鼠喂食对照饮食或HF饮食。随后，给子代喂食普通饲料或HF饮食。使用第五组，即断奶后接受母体/产后HF饮食及白藜芦醇的组（HHR）来研究白藜芦醇治疗的效果。白藜芦醇治疗通过减少采食量或诱导代谢变化，减轻了由母体和产后HF饮食所编程的肥胖。还发现白藜芦醇治疗改善了在由母体和产后HF饮食所编程的腹膜后脂肪组织中观察到的SIRT1丰度降低。此外，白藜芦醇疗法通过DNA甲基化修饰降低血浆瘦素水平并增加腹膜后脂肪组织中的瘦素受体表达。
这些结果表明，白藜芦醇可通过对编码瘦素及其受体的基因进行表观遗传调控，减轻产前和产后HF饮食联合作用所编程的外周瘦素抵抗。它为解释白藜芦醇在肥胖管理中的有益作用的新机制提供了见解。
