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氯喹在抗击 COVID-19 中的作用:好、坏,还是皆有?

Chloroquine in fighting COVID-19: good, bad, or both?

机构信息

The Third Affiliated Hospital, Guangzhou Medical University , Guangzhou, Guangdong, China.

Department of Surgery, UT Southwestern Medical Center , Dallas, TX, USA.

出版信息

Autophagy. 2020 Dec;16(12):2273-2275. doi: 10.1080/15548627.2020.1796014. Epub 2020 Jul 25.

Abstract

Coronavirus disease 2019 (COVID-19) has attracted worldwide attention due to its speed of progression and elevated mortality rate. Amid the rush to develop treatments, recent hopes have focused on the anti-malarial drug chloroquine or the derivative hydroxychloroquine. Here, we briefly discuss the evidence for the potential use of these drugs with regard to the current pandemic.

摘要

新型冠状病毒病 2019(COVID-19)由于其进展速度和高死亡率而引起了全世界的关注。在急于开发治疗方法的过程中,最近的希望集中在抗疟药氯喹或其衍生物羟氯喹上。在这里,我们简要讨论了这些药物在当前大流行中的潜在用途的证据。

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引用本文的文献

本文引用的文献

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The hallmarks of COVID-19 disease.新型冠状病毒疾病的特征。
PLoS Pathog. 2020 May 22;16(5):e1008536. doi: 10.1371/journal.ppat.1008536. eCollection 2020 May.
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The COVID-19 vaccine development landscape.2019冠状病毒病疫苗的研发情况。
Nat Rev Drug Discov. 2020 May;19(5):305-306. doi: 10.1038/d41573-020-00073-5.
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Of chloroquine and COVID-19.关于氯喹和 COVID-19。
Antiviral Res. 2020 May;177:104762. doi: 10.1016/j.antiviral.2020.104762. Epub 2020 Mar 5.
6
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.氯喹和羟氯喹作为对抗新型冠状病毒肺炎的现有武器。
Int J Antimicrob Agents. 2020 Apr;55(4):105932. doi: 10.1016/j.ijantimicag.2020.105932. Epub 2020 Mar 4.
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Structure analysis of the receptor binding of 2019-nCoV.2019新型冠状病毒受体结合的结构分析
Biochem Biophys Res Commun. 2020 Feb 17;525(1):135-40. doi: 10.1016/j.bbrc.2020.02.071.
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