Cortés Alba, Muñoz-Antoli Carla, Esteban J Guillermo, Toledo Rafael
Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot - Valencia, Spain.
Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot - Valencia, Spain.
Trends Parasitol. 2017 Sep;33(9):678-693. doi: 10.1016/j.pt.2017.05.004. Epub 2017 May 26.
Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth of affected populations. However, intestinal helminthiases are still among the most neglected tropical diseases. Protective immunity against intestinal helminths is associated with development of type 2 responses. Nevertheless, in some host-intestinal helminth combinations, local Th1 responses are initiated, inducing chronicity. The usage of helminth-mouse models is useful for elucidating the mechanisms behind the initiation of each type of response. Herein, the current knowledge on these topics is reviewed, paying particular attention to the earliest events of the immune cascade which eventually lead to either susceptibility or resistance to infection.
肠道蠕虫病影响着全球数百万人，主要集中在发展中地区，在这些地区，它们对人类健康以及受影响人群的社会经济增长造成了重大负面影响。然而，肠道蠕虫病仍然是最被忽视的热带疾病之一。针对肠道蠕虫的保护性免疫与2型反应的发展相关。然而，在一些宿主-肠道蠕虫组合中，会启动局部Th1反应，导致疾病慢性化。蠕虫-小鼠模型的使用有助于阐明每种反应启动背后的机制。本文对这些主题的现有知识进行了综述，特别关注免疫级联反应中最终导致感染易感性或抵抗力的最早事件。
