School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Iran.
Department of Occupational Health, Faculty of Public Health, Iran University of Medical Sciences, Iran.
Ind Health. 2020 Dec 4;58(6):492-502. doi: 10.2486/indhealth.2020-0073. Epub 2020 Jul 21.
The rapid growth of nanotechnology has increased the occupational exposure to nanomaterials. On the other hand, a growing body of evidence considers exposure to these materials to be hazardous. Therefore, it is necessary to examine the effects of occupational exposure to these materials by different methods. Biological monitoring, especially the investigation of oxidative stress induced by exposure to nanomaterials, can provide useful information for researchers. This study systematically reviews studies that have investigated oxidative stress caused by occupational exposure to nanomaterials. The search was conducted on the PubMed, Scopus and Web of Science databases. Of the 266 studies we obtained in our initial search, eventually 11 were included in our study. There is currently no specific biomarker for investigating oxidative stress induced by exposure to nanomaterials. Therefore, the reviewed studies have used different biomarkers in different biological fluids for this purpose. Also, the methods of assessing occupational exposure to nanomaterials in the investigated studies were very diverse. Given the approach of the investigated studies to biomarkers and exposure assessment methods, finding a specific biomarker for investigating exposure to nanomaterials seems unattainable. But reaching a group of biomarkers, to assess exposure to nanomaterials seems more applicable and achievable.
纳米技术的快速发展增加了人们接触纳米材料的职业暴露。另一方面，越来越多的证据表明，接触这些材料是有危害的。因此，有必要通过不同的方法来研究职业接触这些材料的影响。生物监测，特别是对接触纳米材料引起的氧化应激的研究，可以为研究人员提供有用的信息。本研究系统地综述了职业接触纳米材料引起的氧化应激的研究。在 PubMed、Scopus 和 Web of Science 数据库中进行了检索。在我们最初的检索中获得了 266 项研究，最终有 11 项被纳入本研究。目前还没有专门用于研究接触纳米材料引起的氧化应激的生物标志物。因此，综述中的研究在不同的生物流体中使用了不同的生物标志物来研究这个问题。此外，研究中评估职业接触纳米材料的方法也非常多样化。鉴于研究中对生物标志物和暴露评估方法的方法，找到一种专门用于研究纳米材料暴露的生物标志物似乎是不可能的。但是，找到一组生物标志物来评估纳米材料的暴露似乎更适用和可行。
