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Behavioral, socio-environmental, educational and demographic correlates of excess body weight in Italian adolescents and young adults.意大利青少年和年轻成年人超重的行为、社会环境、教育和人口统计学相关因素。
Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):279-289. doi: 10.1016/j.numecd.2018.11.009. Epub 2018 Dec 8.
2
Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies.孕期母体肥胖对后代心脏代谢健康的影响：动物研究的系统评价和荟萃分析。
Obes Rev. 2019 May;20(5):675-685. doi: 10.1111/obr.12817. Epub 2019 Jan 11.
3
The impact of maternal gestational weight gain on cardiometabolic risk factors in children.母亲妊娠期体重增加对儿童心血管代谢危险因素的影响。
Diabetologia. 2018 Dec;61(12):2539-2548. doi: 10.1007/s00125-018-4724-x. Epub 2018 Sep 17.
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Maternal high-fat diet acts on the brain to induce baroreflex dysfunction and sensitization of angiotensin II-induced hypertension in adult offspring.母体高脂肪饮食作用于大脑，导致成年后代的压力感受性反射功能障碍和血管紧张素Ⅱ诱导的高血压敏化。
Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H1061-H1069. doi: 10.1152/ajpheart.00698.2017. Epub 2018 Jan 26.
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Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials.孕期基于饮食和身体活动的干预措施对孕期体重增加及妊娠结局的影响：来自随机试验的个体参与者数据的荟萃分析
BMJ. 2017 Jul 19;358:j3119. doi: 10.1136/bmj.j3119.
6
Effect of Gestational Weight Gain and Prepregnancy Body Mass Index in Adolescent Mothers on Weight and Body Mass Index of Adolescent Offspring.青少年母亲孕期体重增加和孕前体质量指数对青少年后代体重和体质量指数的影响。
J Adolesc Health. 2017 Nov;61(5):626-633. doi: 10.1016/j.jadohealth.2017.05.005. Epub 2017 Jul 13.
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Associations of maternal prepregnancy body mass index and gestational weight gain with cardio-metabolic risk factors in adolescent offspring: a prospective cohort study.母亲孕前体重指数和孕期体重增加与青少年后代心血管代谢危险因素的关联：一项前瞻性队列研究。
BJOG. 2016 Jan;123(2):207-16. doi: 10.1111/1471-0528.13700. Epub 2015 Nov 3.
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Associations of maternal weight status prior and during pregnancy with neonatal cardiometabolic markers at birth: the Healthy Start study.孕期前后母亲体重状况与新生儿出生时心脏代谢标志物的关联：健康启动研究
Int J Obes (Lond). 2015 Oct;39(10):1437-42. doi: 10.1038/ijo.2015.109. Epub 2015 Jun 9.
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Diabetes. 2015 Sep;64(9):3111-20. doi: 10.2337/db14-1627. Epub 2015 May 6.
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Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS).孕期母亲体重与成年后期子代身体组成：赫尔辛基出生队列研究（HBCS）的结果
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母体肥胖：关注子代的心血管代谢结局。

Maternal obesity: focus on offspring cardiometabolic outcomes.

作者信息

Gambineri Alessandra, Conforti Alessandro, Di Nisio Andrea, Laudisio Daniela, Muscogiuri Giovanna, Barrea Luigi, Savastano Silvia, Colao Annamaria

机构信息

Endocrinology Unit, Department of Medical and Surgical Sciences, St Orsola-Malpighi Hospital, Alma Mater University of Bologna, Bologna, Italy.

Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.

出版信息

Int J Obes Suppl. 2020 Jul;10(1):27-34. doi: 10.1038/s41367-020-0016-2. Epub 2020 Jul 20.

DOI:10.1038/s41367-020-0016-2
PMID:32714510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7371867/
Abstract

Several human and animal studies have demonstrated that cardiometabolic parameters in infancy, childhood, adolescence and even adulthood are negatively influenced by many factors besides energy imbalance. Interestingly, maternal weight excess both before and during pregnancy seems to be a negative determinant of metabolic and cardiovascular outcomes in the offspring. This review includes both human and animal studies and finally highlights the link between maternal obesity and cardiometabolic disorders in offspring.

摘要

多项人体和动物研究表明，除能量失衡外，婴儿期、儿童期、青春期乃至成年期的心脏代谢参数还受到许多因素的负面影响。有趣的是，孕期前后母亲体重超标似乎是后代代谢和心血管结局的一个负面决定因素。这篇综述涵盖了人体和动物研究，最后强调了母亲肥胖与后代心脏代谢紊乱之间的联系。