母体肥胖：关注子代的心血管代谢结局。
Maternal obesity: focus on offspring cardiometabolic outcomes.
作者信息
Gambineri Alessandra, Conforti Alessandro, Di Nisio Andrea, Laudisio Daniela, Muscogiuri Giovanna, Barrea Luigi, Savastano Silvia, Colao Annamaria
机构信息
Endocrinology Unit, Department of Medical and Surgical Sciences, St Orsola-Malpighi Hospital, Alma Mater University of Bologna, Bologna, Italy.
Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
出版信息
Int J Obes Suppl. 2020 Jul;10(1):27-34. doi: 10.1038/s41367-020-0016-2. Epub 2020 Jul 20.
Abstract
Several human and animal studies have demonstrated that cardiometabolic parameters in infancy, childhood, adolescence and even adulthood are negatively influenced by many factors besides energy imbalance. Interestingly, maternal weight excess both before and during pregnancy seems to be a negative determinant of metabolic and cardiovascular outcomes in the offspring. This review includes both human and animal studies and finally highlights the link between maternal obesity and cardiometabolic disorders in offspring.
摘要
多项人体和动物研究表明，除能量失衡外，婴儿期、儿童期、青春期乃至成年期的心脏代谢参数还受到许多因素的负面影响。有趣的是，孕期前后母亲体重超标似乎是后代代谢和心血管结局的一个负面决定因素。这篇综述涵盖了人体和动物研究，最后强调了母亲肥胖与后代心脏代谢紊乱之间的联系。
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