Department of Gastroenterology, Vall d'Hebron University Hospital, Barcelona, Spain.
Department of Gastroenterology and Hepatology, University Medical Centers Amsterdam, Amsterdam, The Netherlands.
Neurogastroenterol Motil. 2021 Jan;33(1):e13954. doi: 10.1111/nmo.13954. Epub 2020 Jul 26.
Establishing normative values of high-resolution esophageal manometry is necessary for accurate interpretation and comparison of measurements. In this systematic review, we aimed to summarize normal values for different esophageal high-resolution manometry systems. Moreover, we assessed the effect of body position, bolus consistency, and provocative maneuvers on these normative thresholds. We searched Medline, Embase, and the Cochrane Library from January 1st, 2006, to January 20th, 2020, for studies that reported normative data of high-resolution manometry in healthy volunteers. We assessed methodological quality of the included studies and planned a descriptive analysis. We analyzed data from 54 articles describing normative thresholds in high-resolution manometry using solid-state or water-perfused systems. Forty-six studies performed the manometry study in the supine position with liquid swallows, whereas sixteen studies described normative values in the upright position. Twelve studies assessed normative values for different bolus consistencies, and nine studies evaluated different provocative maneuvers. There is a considerable variety of normative values for esophageal high-resolution manometry depending on the equipment used and the protocols performed to obtain measurements. This should be taken into account when evaluating measurements in clinical practice and when comparing results of published research studies.
建立高分辨率食管测压的正常值对于准确解释和比较测量结果是必要的。在这项系统评价中，我们旨在总结不同食管高分辨率测压系统的正常值。此外，我们评估了体位、吞咽物稠度和激发试验对这些正常阈值的影响。我们检索了 Medline、Embase 和 Cochrane 图书馆，检索时间为 2006 年 1 月 1 日至 2020 年 1 月 20 日，以寻找报道健康志愿者高分辨率测压正常值的研究。我们评估了纳入研究的方法学质量，并计划进行描述性分析。我们分析了 54 篇描述使用固态或水灌注系统进行高分辨率测压的正常阈值的文章的数据。46 项研究在仰卧位进行液体吞咽测压，而 16 项研究描述了直立位的正常值。12 项研究评估了不同吞咽物稠度的正常值，9 项研究评估了不同激发试验。食管高分辨率测压的正常值因使用的设备和获得测量值的方案而异，存在很大的差异。在临床实践中评估测量值和比较已发表的研究结果时，应考虑到这一点。
