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在使用奥妥珠单抗和苯丁酸氮芥治疗期间里氏综合征的发生情况。

The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil.

作者信息

Ng Teng Fong, Carnley Benedict, Green Celia, Spagnolo Dominic, Leahy Michael F

机构信息

Royal Perth Hospital, Perth, WA, Australia.

PathWest Laboratory Medicine, Perth, WA, Australia.

出版信息

Case Rep Hematol. 2020 Jul 16;2020:8363427. doi: 10.1155/2020/8363427. eCollection 2020.

DOI:10.1155/2020/8363427
PMID:32724682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7381955/
Abstract

Chronic lymphocytic leukaemia is a slow-growing leukaemia of developing B-lymphocytes, which may transform to an aggressive lymphoma known as Richter's syndrome. While Richter's syndrome can present in untreated or relapsed-refractory cases, it may occur upon the commencement of less intensity treatment regimens. We present a case of Richter's syndrome following treatment with chlorambucil and obinutuzumab and review of available literature on the topic.

摘要

慢性淋巴细胞白血病是一种发展缓慢的B淋巴细胞白血病，可能会转化为一种侵袭性淋巴瘤，即里氏综合征。虽然里氏综合征可出现在未经治疗或复发难治的病例中，但也可能在强度较低的治疗方案开始后出现。我们报告一例在用苯丁酸氮芥和奥妥珠单抗治疗后发生里氏综合征的病例，并对该主题的现有文献进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eff/7381955/bc839db69220/CRIHEM2020-8363427.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eff/7381955/a8010a4d3aca/CRIHEM2020-8363427.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eff/7381955/bc839db69220/CRIHEM2020-8363427.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eff/7381955/a8010a4d3aca/CRIHEM2020-8363427.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eff/7381955/bc839db69220/CRIHEM2020-8363427.002.jpg

相似文献

1
The Occurrence of Richter's Syndrome during Treatment with Obinutuzumab and Chlorambucil.在使用奥妥珠单抗和苯丁酸氮芥治疗期间里氏综合征的发生情况。
Case Rep Hematol. 2020 Jul 16;2020:8363427. doi: 10.1155/2020/8363427. eCollection 2020.
2
Richter's syndrome: a case report.里氏综合征：一例病例报告。
Med Princ Pract. 2009;18(2):152-4. doi: 10.1159/000189815. Epub 2009 Feb 10.
3
Hodgkin's disease variant of Richter's syndrome clonally related to chronic lymphocytic leukemia arises in ZAP-70 negative mutated CLL.与慢性淋巴细胞白血病克隆相关的里氏综合征霍奇金病变异型起源于ZAP-70阴性突变的慢性淋巴细胞白血病。
Med Hypotheses. 2006;66(3):577-9. doi: 10.1016/j.mehy.2005.09.007. Epub 2005 Oct 11.
4
Bendamustine followed by obinutuzumab and venetoclax in chronic lymphocytic leukaemia (CLL2-BAG): primary endpoint analysis of a multicentre, open-label, phase 2 trial.苯达莫司汀后继奥滨尤妥珠单抗和维奈克拉治疗慢性淋巴细胞白血病（CLL2-BAG）：多中心、开放标签、2 期试验的主要终点分析。
Lancet Oncol. 2018 Sep;19(9):1215-1228. doi: 10.1016/S1470-2045(18)30414-5. Epub 2018 Aug 13.
5
A cultured malignant B-1 line serves as a model for Richter's syndrome.一种培养的恶性B-1细胞系可作为里氏综合征的模型。
J Immunol. 1994 Aug 15;153(4):1869-80.
6
Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.慢性淋巴细胞白血病转化为Richter综合征时的微卫星不稳定性和hMLH1启动子高甲基化
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Epstein-Barr virus infection in Richter's transformation.里氏转化中的爱泼斯坦-巴尔病毒感染
Am J Hematol. 1999 Feb;60(2):99-104. doi: 10.1002/(sici)1096-8652(199902)60:2<99::aid-ajh3>3.0.co;2-t.
8
Richter's syndrome: biology and therapy.里氏综合征：生物学与治疗
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9
Hodgkin's disease variant of Richter's syndrome. Report of a case with diagnosis by fine needle biopsy.里氏综合征的霍奇金病变异型。1例经细针穿刺活检确诊的病例报告。
Acta Cytol. 1997 May-Jun;41(3):823-9. doi: 10.1159/000332710.
10
Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT.通过PET/CT检测慢性淋巴细胞白血病的 Richter 转化
J Nucl Med. 2006 Aug;47(8):1267-73.

本文引用的文献

1
Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia.慢性淋巴细胞白血病临床演变过程中的克隆动力学监测。
Sci Rep. 2019 Jan 30;9(1):975. doi: 10.1038/s41598-018-37389-7.
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Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial.伊布替尼联合奥滨尤妥珠单抗与苯丁酸氮芥联合奥滨尤妥珠单抗一线治疗慢性淋巴细胞白血病（ILLUMINATE）：一项多中心、随机、开放标签、III 期临床试验。
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Bendamustine followed by obinutuzumab and venetoclax in chronic lymphocytic leukaemia (CLL2-BAG): primary endpoint analysis of a multicentre, open-label, phase 2 trial.
苯达莫司汀后继奥滨尤妥珠单抗和维奈克拉治疗慢性淋巴细胞白血病（CLL2-BAG）：多中心、开放标签、2 期试验的主要终点分析。
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Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax.依鲁替尼治疗后慢性淋巴细胞白血病进展的临床病理特征和结局。
Blood. 2017 Jun 22;129(25):3362-3370. doi: 10.1182/blood-2017-01-763003. Epub 2017 May 4.
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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.在复发的慢性淋巴细胞白血病中使用维奈托克靶向BCL2
N Engl J Med. 2016 Jan 28;374(4):311-22. doi: 10.1056/NEJMoa1513257. Epub 2015 Dec 6.
7
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib.初治和既往接受过治疗的慢性淋巴细胞白血病（CLL）和小淋巴细胞淋巴瘤（SLL）患者接受单药伊布替尼治疗的三年随访
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Ofatumumab and bendamustine in previously treated chronic lymphocytic leukemia and small lymphocytic lymphoma.奥法木单抗与苯达莫司汀用于既往治疗过的慢性淋巴细胞白血病和小淋巴细胞淋巴瘤。
Leuk Lymphoma. 2015 Apr;56(4):915-20. doi: 10.3109/10428194.2014.933217. Epub 2014 Aug 6.
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Herpes simplex virus lymphadenitis.
Blood. 2014 Jan 2;123(1):12. doi: 10.1182/blood-2013-09-524272.
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How we treat Richter syndrome.我们如何治疗里希特综合征。
Blood. 2014 Mar 13;123(11):1647-57. doi: 10.1182/blood-2013-11-516229. Epub 2014 Jan 13.