Carvalho Aline Cunha, Mota Maria Carliana, Marot Luisa Pereira, Mattar Luís Augusto, de Sousa José Américo Gomides, Araújo Ana Cristina Tomaz, da Costa Assis Camila Thaís, Crispim Cibele Aparecida
Faculty of Medicine, Federal University of Uberlandia, Avenue. Pará, 1720, Bloco 2U, Room 20. Campus Umuarama, Uberlandia, MG, 38405-320, Brazil.
LEV clinic - Treatment of Obesity, Uberlandia, Brazil.
Obes Surg. 2021 Jan;31(1):159-169. doi: 10.1007/s11695-020-04873-x. Epub 2020 Jul 29.
Circadian misalignment has been associated with an increased risk of overweight and obesity, as well as changes in metabolic parameters. This study evaluated the association between social jet lag (SJL), a measure of circadian misalignment, and anthropometric, metabolic and food intake outcomes 6 months after bariatric surgery.
A total of 122 bariatric patients were included (77% female, aged 33 years (range 28-41); 79.5% underwent Roux-en-Y gastric bypass). Anthropometric, food consumption and SJL were evaluated in the preoperative evaluation and in the third and sixth months after surgery. SJL was calculated based on the absolute difference between the mid-sleep time on weekends and weekdays. Generalised estimating equations and linear regression were performed to evaluate the associations between mean SJL exposure and the outcomes.
The interaction between SJL and follow-up time negatively influenced the evolution of weight (p = 0.01), BMI (p = 0.04) and insulin levels (p = 0.01). SJL had an effect on intake of calories (p = 0.001), carbohydrate (p = 0.005) and total (p = 0.007), monounsaturated (p = 0.03) and polyunsaturated fat (p < 0.001). Linear regression showed a negative association between mean SJL exposure over the 6 months and the percentage of weight loss (coefficient = - 0.30, p = 0.006), body weight loss (kg) (coefficient = - 0.17, p = 0.03) and the reduction of BMI (coefficient = - 0.24, p = 0.007).
SJL was negatively associated with anthropometric, metabolic and food consumption outcomes 6 months after bariatric surgery. Future studies with longer follow-up are needed to confirm these findings.
Clinical Trials.gov : NCT03485352.
昼夜节律失调与超重和肥胖风险增加以及代谢参数变化有关。本研究评估了社交时差（SJL，一种昼夜节律失调的指标）与减肥手术后6个月的人体测量、代谢和食物摄入结果之间的关联。
共纳入122例减肥手术患者（77%为女性，年龄33岁（范围28 - 41岁）；79.5%接受了Roux-en-Y胃旁路手术）。在术前评估以及术后第三个月和第六个月评估人体测量、食物消耗和SJL情况。SJL基于周末和工作日的中间睡眠时间的绝对差异计算得出。采用广义估计方程和线性回归来评估平均SJL暴露与结果之间的关联。
SJL与随访时间之间的相互作用对体重（p = 0.01）、BMI（p = 0.04）和胰岛素水平（p = 0.01）的变化产生负面影响。SJL对卡路里摄入量（p = 0.001）、碳水化合物摄入量（p = 0.005）以及总脂肪摄入量（p = 0.007）、单不饱和脂肪摄入量（p = 0.03）和多不饱和脂肪摄入量（p < 0.001）有影响。线性回归显示，6个月内平均SJL暴露与体重减轻百分比（系数 = -0.30，p = 0.006）、体重减轻量（kg）（系数 = -0.17，p = 0.03）和BMI降低值（系数 = -0.24，p = 0.007）呈负相关。
减肥手术后6个月，SJL与人体测量、代谢和食物消耗结果呈负相关。需要进行更长随访时间的未来研究来证实这些发现。
ClinicalTrials.gov：NCT03485352。
