铁死亡相关基因特征预测胶质瘤细胞死亡和胶质瘤患者病情进展。
Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression.
作者信息
Liu Han-Jie, Hu Hui-Min, Li Guan-Zhang, Zhang Ying, Wu Fan, Liu Xiu, Wang Kuan-Yu, Zhang Chuan-Bao, Jiang Tao
机构信息
Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China.
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
出版信息
Front Cell Dev Biol. 2020 Jul 9;8:538. doi: 10.3389/fcell.2020.00538. eCollection 2020.
Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.
胶质瘤是一种致命的脑肿瘤，其特征为快速增殖和治疗抵抗。铁死亡是一种新发现的程序性细胞死亡，在肿瘤的发生和发展中起关键作用。在本研究中，我们通过分析来自中国胶质瘤基因组图谱、癌症基因组图谱数据集、GSE16011数据集和分子脑肿瘤数据存储库数据集的全转录组数据，鉴定了铁死亡特异性标志物，以揭示铁死亡相关基因与胶质瘤之间的关系。鉴定出19个与胶质瘤临床和病理特征相关的铁死亡相关基因高度相关。胶质瘤细胞系中的功能分析表明铁死亡与替莫唑胺耐药、自噬和胶质瘤细胞迁移有关。因此，鉴定出的铁死亡相关基因与胶质瘤进展显著相关。
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