Lu Mengyang, Zhou Yuanshuai, Sun Linjuan, Shafi Shaheryar, Ahmad Nafees, Sun Minxuan, Dong Jun
Noncoding RNA and Cancer Lab, Faculty of Life Sciences, Shanghai University, Shanghai, China.
Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.
Front Oncol. 2022 Aug 16;12:917537. doi: 10.3389/fonc.2022.917537. eCollection 2022.
Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment options are very limited. Ferroptosis plays a critical role in the glioma progression, affecting tumor cell proliferation, angiogenesis, tumor necrosis, and shaping the immune-resistant tumor microenvironment. Inducing ferroptosis has emerged as an attractive strategy for glioma. In this paper, we review ferroptosis-related researches on glioma progression and treatment.
铁死亡是一种最近引起广泛关注的程序性细胞死亡模式，能够影响许多肿瘤的发展进程和预后。胶质瘤是中枢神经系统最常见的原发性肿瘤之一，但有效的治疗选择非常有限。铁死亡在胶质瘤进展中起关键作用，影响肿瘤细胞增殖、血管生成、肿瘤坏死，并塑造免疫抵抗性肿瘤微环境。诱导铁死亡已成为一种有吸引力的胶质瘤治疗策略。在本文中，我们综述了与胶质瘤进展和治疗相关的铁死亡研究。
