双相障碍患者与原发性和继发性奖励相关的神经回路的静息态功能连接。
Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.
机构信息
Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China.
Present Office, The Psychiatric Hospital of Zhumadian, Zhumadian, Henan 463000, China.
出版信息
Soc Cogn Affect Neurosci. 2020 Sep 24;15(7):755-763. doi: 10.1093/scan/nsaa100.
OBJECTIVE
We used resting-state functional connectivity (rsFC) to evaluate the integrity of the neural circuits associated with primary and secondary rewards in bipolar disorder (BD) with different mood phases.
METHODS
Sixty patients with BD [21 patients with depressive episode of BD (BDD) and 41 patients with maniac episode of BD (BDM)] and 42 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging. rsFC was assessed using region of interest-wise analyses.
RESULTS
Attenuation of rsFC at the orbitofrontal cortex (OFC) and the left ventral striatum (LVS) was observed in the secondary reward circuit of patients with BD compared to that of HCs. Among BDD, BDM and HCs, the rsFC between OFC and LVS in BDM was intermediate, while the rsFC between OFC and right ventral striatum/right amygdala in BDM was the highest; the corresponding rsFC values in BDD were the lowest. Furthermore, a positive correlation was found between rsFC and Young Mania Rating Scale scores in BDM.
CONCLUSIONS
This study suggests that there may be an abnormal rsFC between OFC and LVS in the second reward of patients with BD and the discrepant patterns of rsFC may exist between different mood states in patients with BD.
目的
我们使用静息态功能连接（rsFC）来评估双相障碍（BD）不同情绪阶段与原发性和继发性奖励相关的神经回路的完整性。
方法
60 名 BD 患者[21 名 BD 抑郁发作患者（BDD）和 41 名 BD 躁狂发作患者（BDM）]和 42 名健康对照者（HCs）接受了静息态功能磁共振成像。采用基于感兴趣区的分析评估 rsFC。
结果
与 HCs 相比，BD 患者的次级奖励回路中观察到眶额皮质（OFC）和左侧腹侧纹状体（LVS）的 rsFC 减弱。在 BDD、BDM 和 HCs 中，BDM 中 OFC 和 LVS 之间的 rsFC 处于中间水平，而 BDM 中 OFC 和右侧腹侧纹状体/右侧杏仁核之间的 rsFC 最高；BDD 的相应 rsFC 值最低。此外，BDM 中 rsFC 与 Young 躁狂评定量表评分呈正相关。
结论
本研究表明，BD 患者的第二奖励中 OFC 和 LVS 之间可能存在异常的 rsFC，并且 BD 患者不同情绪状态之间可能存在不同的 rsFC 模式。
Zotero 插件