儿童甲型流感病毒和乙型流感病毒感染的细胞免疫表型表达。
The cellular immunophenotype expression of influenza A virus and influenza B virus infection in children.
机构信息
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan.
出版信息
Clin Immunol. 2020 Oct;219:108548. doi: 10.1016/j.clim.2020.108548. Epub 2020 Jul 29.
BACKGROUND
The innate immune response is the primary defense against influenza virus infection.
METHODS
This is a prospective study carried out in children <18 years of age who were diagnosed with influenza A or influenza B infection. Demographic and clinical data, laboratory findings and cell immunophenotypes on first presentation were compared.
RESULTS
With respect to immunophenotype, influenza A infection resulted in a higher fraction of CD14 and CD4IL-17Acells compared to children infected with influenza B. By contrast, influenza B infection resulted in a comparatively higher percentage of double-negative CD4CD8 lymphocyte subsets. Influenza A infection was associated with comparatively higher percentages of CD4CD25Foxp3 and CD4CD25Foxp3 cells. By contrast, the percentage of CD8CD25 and CD8CD25 cells was similar among patients with influenza A infection and influenza B infection.
CONCLUSIONS
An improved understanding of the fraction of regulatory T cells with influenza virus infections may provide further understandings on immune responses.
背景
先天免疫反应是抵抗流感病毒感染的主要防御机制。
方法
这是一项在 <18 岁的被诊断为甲型或乙型流感病毒感染的儿童中进行的前瞻性研究。比较了初次就诊时的人口统计学和临床数据、实验室发现和细胞免疫表型。
结果
就免疫表型而言，与感染乙型流感的儿童相比，甲型流感感染导致 CD14 和 CD4IL-17A 细胞的比例更高。相比之下，乙型流感感染导致双阴性 CD4CD8 淋巴细胞亚群的比例相对较高。甲型流感感染与 CD4CD25Foxp3 和 CD4CD25Foxp3 细胞的比例相对较高有关。相比之下，甲型流感感染和乙型流感感染患者的 CD8CD25 和 CD8CD25 细胞比例相似。
结论
对流感病毒感染中调节性 T 细胞比例的深入了解可能有助于进一步了解免疫反应。
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