Laboratory of Pathogen Infection and Immunity, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, People's Republic of China.
Laboratory of Pathogen Infection and Immunity, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, People's Republic of China.
Trends Parasitol. 2020 Sep;36(9):773-784. doi: 10.1016/j.pt.2020.07.001. Epub 2020 Jul 28.
Emerging evidence suggests that the DNA-sensing pathway plays a crucial role in innate immunity against multiple diseases, especially infectious diseases. Cyclic GMP-AMP synthase (cGAS), as a DNA sensor, and stimulator of interferon (IFN) genes (STING), as an adaptor protein, are the central components that link DNA sensing to immunologic functions - including, but not limited to, the type I IFN response. Recently, a series of studies have revealed that genomic DNA from protozoan parasites triggers the cGAS-STING pathway, and these studies identified the positive and negative regulators that modulate the signaling in parasite infection. Here, we summarize current understanding of the critical functions and potential applications of the cGAS-STING axis in parasitic diseases, specifically those caused by malaria parasites.
新出现的证据表明，DNA 感应途径在针对多种疾病（尤其是传染病）的先天免疫中起着至关重要的作用。环鸟苷酸-腺苷酸合酶 (cGAS) 作为 DNA 传感器，干扰素基因刺激物 (STING) 作为衔接蛋白，是将 DNA 感应与免疫功能联系起来的核心组成部分——包括但不限于 I 型干扰素反应。最近，一系列研究揭示了原生动物寄生虫的基因组 DNA 触发了 cGAS-STING 途径，这些研究确定了调节寄生虫感染中信号转导的正负调节剂。在这里，我们总结了 cGAS-STING 轴在寄生虫病（特别是疟疾寄生虫引起的疾病）中的关键功能和潜在应用的现有认识。
