内源性大麻素系统在记忆更新与遗忘中的作用。
Effect of the Endocannabinoid System in Memory Updating and Forgetting.
作者信息
Lunardi Paula, de Souza Laura W, Dos Santos Bruna, Popik Bruno, de Oliveira Alvares Lucas
机构信息
Laboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Brazil.
Laboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brazil.
出版信息
Neuroscience. 2020 Sep 15;444:33-42. doi: 10.1016/j.neuroscience.2020.07.045. Epub 2020 Jul 30.
Most memories of life experiences will be forgotten or modified over time. Although several studies have investigated the processes underlying memory formation, the mechanisms behind memory updating and forgetting remain unclear. The endocannabinoid system has been shown to be closely involved in various memory processes such as consolidation, destabilization, and extinction. Here, we investigate the role of the endocannabinoid system in memory updating, behavioral flexibility, and forgetting. We found that the hippocampal infusion of CB1 antagonist prevented memory updating in the immediate footshock (context pre-exposure facilitation effect) and reversal learning. Also, CB1 antagonist accelerated forgetting in inhibitory avoidance. Thus, by indicating the important role played by the endocannabinoid system, our results extend current knowledge of the mechanisms underpinning memory updating and forgetting.
随着时间的推移，大多数生活经历的记忆会被遗忘或改变。尽管有几项研究调查了记忆形成背后的过程，但记忆更新和遗忘背后的机制仍不清楚。内源性大麻素系统已被证明与各种记忆过程密切相关，如巩固、不稳定和消退。在这里，我们研究内源性大麻素系统在记忆更新、行为灵活性和遗忘中的作用。我们发现，向海马体注射CB1拮抗剂可阻止即时足部电击（情境预暴露促进效应）和逆向学习中的记忆更新。此外，CB1拮抗剂加速了抑制性回避中的遗忘。因此，通过表明内源性大麻素系统所起的重要作用，我们的结果扩展了目前对记忆更新和遗忘背后机制的认识。
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