多种别构组分和机制控制芳香代谢物生物合成的进入。
Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis.
机构信息
Ferrier Research Institute, Victoria University of Wellington, Wellington, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery, Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand.
出版信息
Curr Opin Struct Biol. 2020 Dec;65:159-167. doi: 10.1016/j.sbi.2020.06.015. Epub 2020 Jul 30.
Allosteric regulation of the enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) controls the entry into aromatic amino acid biosynthesis in plants and microorganisms. DAH7PS has acquired a diverse range of allosteric machinery to enable this functionality. This review provides an overview of the current knowledge of the structural basis of allostery in this enzyme family and the evolutionary relationships between the different solutions to allosteric control of aromatic metabolite biosynthesis.
酶 3-脱氧-d-阿拉伯庚酮糖-7-磷酸合酶（DAH7PS）的变构调节控制着植物和微生物中芳香族氨基酸生物合成的进入。DAH7PS 获得了各种变构机制来实现这一功能。本文综述了该酶家族变构作用的结构基础以及不同芳香族代谢物生物合成变构控制解决方案之间的进化关系的最新知识。
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